Acute　lung　injury　(ALI)　is　one　of　the　most　common　and　highly　prevailing　respiratory　system　diseases.　However,　there　is　still　a　lack　of　effective　specialized　medicines　for　the　treatment　of　ALI.　Biocompatible　gold　nanoclusters　(AuNCs)　have　shown　great　potential　in　alleviating　ALI,　but　their　lung-targeted　delivery　needs　to　be　enhanced.　In　recent　years,　lipid　nanoparticles　(LNPs)　have　become　the　most　promising　delivery　system　for　clinical　application　and　achieved　great　success　in　mRNA　vaccines　during　the　COVID-19　pandemic.　Herein,　we　constructed　a　lung-delivery　formulation　of　AuNCs　by　encapsulating　glutathione-coated　gold　nanoclusters　(GA)　in　lung-delivery　ionizable　lipid　nanoparticles　(iLNPs)　and　termed　it　as　GA@iLNP.　Results　indicated　that　GA@iLNP　can　promote　the　cellular　uptake　of　GA　and　enhance　the　anti-inflammation　efficiency　in　stimulated　macrophages　in　vitro.　In　addition,　iLNP　encapsulation　significantly　increased　the　lung　accumulation　of　GA　in　lipopolysaccharide　(LPS)-induced　ALI　mice　after　intravenous　injection　and　enhanced　the　alleviations　of　inflammation　and　tissue　damage　in　the　lungs.　These　results　suggest　that　organ-selective　iLNPs　may　be　an　ideal　targeted　delivery　system　for　AuNCs,　providing　a　powerful　tool　for　translational　applications　of　bioactive　AuNCs.