Background:　Wound　healing　is　a　complex　and　intricate　biological　process　that　involves　multiple　systems　within　the　body　and　initiates　a　series　of　highly　coordinated　responses　to　repair　damage　and　restore　integrity　and　functionality.　We　previously　identified　that　breathing　hydrogen　can　significantly　inhibit　early　inflammation,　activate　autologous　stem　cells,　and　promote　the　accumulation　of　extracellular　matrix　(ECM).　However,　the　broader　functions　and　downstream　targets　of　hydrogen-induced　ECM　accumulation　and　tissue　remodeling　are　unknown　in　the　wound-healing　process.　Methods:　Consequently,　this　thesis　developed　a　hydrogen　sustained-release　dressing　based　on　a　micro　storage　material　and　reveals　the　mechanism　of　hydrogen　in　treating　wound　healing.　Upon　encapsulating　the　hydrogen　storage　materials,　magnesium　(Mg),　and　ammonia　borane　(AB),　we　found　that　SiO2@Mg　exhibits　superior　sustained-release　performance,　while　SiO2@AB　demonstrates　a　higher　hydrogen　storage　capacity.　We　used　a　C57/BL6　mouse　full-thickness　skin　defect　wound　model　to　analyze　and　compare　different　hydrogen　dressings.　Results:　It　was　identified　that　hydrogen　dressings　can　significantly　improve　the　healing　rate　of　wounds　by　promoting　epithelialization,　angiogenesis,　and　collagen　accumulation　in　wound　tissue,　and　that　the　effect　of　slow-release　dressings　is　better　than　of　non-slow-release　dressings.　We　also　found　that　hydrogen　dressing　can　promote　transcriptome-level　expression　related　to　cell　proliferation　and　differentiation　and　ECM　accumulation,　mainly　through　the　Wnt1/beta-catenin　pathway　and　TGF-beta　1/Smad2　pathway.　Conclusions:　Overall,　these　results　provide　a　novel　insight　into　the　field　of　hydrogen　treatment　and　wound　healing.