Manufactured　sand　(MS)　is　a　beneficial　and　sustainable　supplement　to　natural　sand　(NS).　This　study　investigated　the　mechanical　properties　of　manufactured　sand　concrete　(MSC)　columns　under　axial　compression.　The　effects　of　test　parameters　including　MS　replacement　rate,　reinforcement　ratio,　slenderness　ratio,　and　steel　fiber　content　on　the　failure　modes,　concrete　strain,　stiffness,　and　flexibility,　etc.,　were　analyzed　and　demonstrated.　The　results　showed　that　the　MS　replacement　rate　and　reinforcement　rate　presented　less　effect　on　the　concrete　strain,　whereas　decreasing　the　slenderness　ratio　of　the　specimens　and　increasing　the　steel　fiber　contents　significantly　increased　the　strain　of　the　concrete.　The　100%　MS　replacement　rate　exhibited　little　effect　on　the　strain　of　concrete　and　the　stiffness　of　members,　while　the　bearing　capacity　was　increased　to　9.3%　compared　with　the　0%　MS　replacement　rate.　Incorporating　steel　fibers　significantly　improved　MSC＇s　mechanical　properties　and　increased　the　members＇　strength　and　flexibility.　In　addition,　the　constitutive　model　of　MSC　was　established,　and　the　model＇s　accuracy　was　verified　based　on　finite　element　analysis,　which　exhibited　favorable　accuracy　with　an　error　of　less　than　5%.