China　is　one　of　the　countries　with　highest　burden　of　hepatitis　B　in　the　world,　the　number　of　new　infections　each　year　is　at　a　high　level　and　increases　year　by　year.　The　number　of　infections　in　people　aged　15　years　and　older　accounts　for　97.5%　of　all　cases.　Vaccination　is　the　most　effective　way　of　reducing　the　risk　of　disease　transmission.　It　is　essential　to　assess　the　role　of　vaccination　or　booster　vaccination　in　adult　populations.　In　this　paper,　the　hepatitis　B　cases　data　in　different　age　groups　were　analyzed,　an　age　heterogeneous　hepatitis　B　transmission　dynamics　model　including　multiple　age　groups　and　vaccination　was　established.　Fitting　the　cumulative　case　data　of　hepatitis　B　and　obtaining　the　model　parameters.　Sensitivity　analysis　of　the　basic　reproduction　number　R0　shows　that　vaccination　of　the　population　aged　25-70　can　significantly　reduce　the　number　of　hepatitis　B　cases.　Exploring　the　impact　of　different　vaccination　immunization　strategies　on　the　number　of　hepatitis　B　cases,　we　get　that　it　is　the　most　effective　to　vaccinate　people　aged　15-70,　which　can　reduce　the　cumulative　number　of　hepatitis　B　cases　by　about　60%.　Only　reducing　the　contact　between　people　does　not　help　to　significantly　reduce　the　number　of　hepatitis　B　cases,　but　vaccination　helps　to　greatly　reduce　the　number　of　hepatitis　B　cases.