Continued　seawater　incursion　significantly　affects　the　fate　of　pollutants　in　coastal　estuaries,　yet　understanding　of　the　in-situ　behavior　of　endocrine-disrupting　compounds　(EDCs)　in　these　areas　remains　limited.　The　distribution,　transport　and　microbial　response　of　two　model　EDCs,　bisphenol　A　(BPA)　and　nonylphenol　(NP),　in　three　estuarine　zones　of　slight　(SZ),　moderate　(MZ)　and　complete　(CZ)　seawater　incursion　were　investigated　in-situ.　Results　showed　seawater　incursion　reshaped　the　environmental　gradients　of　the　coastal　estuaries　on　a　spatial　scale.　Varying　salinity　gradient　and　tidal　hydrodynamic　conditions　altered　the　dependence　of　EDCs　on　organic　carbon,　and　promoted　the　release　of　accumulated　EDCs　from　estuarine　sediments　resulting　in　the　lowest　residues　of　BPA　(2.74　+/-　0.76　mu　g/kg)　and　NP　(10.25　+/-　5.86　mu　g/kg)　in　the　MZ.　The　resupply　potential　of　BPA　(R　=　0.171　+/-　0.058)　and　NP　(R　=　0.107　+/-　0.015)　from　sediment　to　porewater　was　significantly　higher　in　the　SZ　than　in　other　zones　(p　＜　0.001),　due　to　both　higher　contaminant　accumulation　in　this　zone　and　inhibited　resupply　in　MZ　and　CZ　caused　by　seawater　incursion.　Furthermore,　seawater　incursion　significantly　reduced　the　microbial　community　diversity　in　the　CZ　(p　＜　0.001),　being　dominated　by　Vibrio　(67.00　+/-　1.13　%),　and　accordingly　weakened　the　ability　to　transform　organic　matter　in　this　region.　Based　on　predicted　sea　level　rise　and　the　transport　characteristics　of　EDCs　under　increased　seawater　incursion,　it　is　estimated　that　the　cumulative　additional　release　of　BPA　and　NP　in　the　estuary　will　reach　1.8　and　1.5　tons　by　2100,　respectively.　In　order　to　mitigate　the　risk　of　additional　estuarine　EDCs　release　due　to　seawater　incursion,　increasing　vegetation　cover,　strict　monitoring,　and　climate　policy　interventions　may　be　effective　strategies.