Sucralose　(SUC)　pose　a　potential　threat　to　the　aquatic　environment　and　human　health.　In　the　study,　SUC　degradation　by　UV/persulfate　(UV/PS)　and　UV/periodate　(UV/PI)　was　compared　from　different　perspectives.　The　results　showed　that　both　processes　were　effective　in　degrading　SUC　within　15　min,　but　the　degradation　rate　of　UV/PI　was　much　higher　than　that　of　UV/PS　due　to　higher　radical　concentrations.　UV/PS　and　UV/PI　are　more　suitable　for　the　degradation　of　SUC　under　neutral　and　alkaline　conditions.　The　presence　of　Cl−　and　HCO3−　mainly　inhibited　SUC　degradation　by　UV/PI,　while　NO3−　was　more　likely　to　inhibit　SUC　degradation　by　UV/PS.　•OH　and　SO4•−　in　UV/PS　degraded　SUC　mainly　by　hydroxylation,　hydrogen　atom　abstraction,　dehydration,　and　direct　oxidation.　In　UV/PI,　in　addition　to　the　above-mentioned　actions,　IO3•　initiates　a　deep　oxidation　process　by　destroying　the　ether　bonds.　After　15　min　of　oxidation,　dechlorination　of　SUC　by　UV/PI　and　UV/PS　was　35.1　%　and　22.9　%.　Dechlorination　is　mainly　achieved　by　the　chlorine　atoms　abstraction　from　•OH　and　the　single　electron　transfer　of　IO3•.　UV/PI　is　recommended　as　a　SUC　degradation　process　with　lower　cost　(55.8　%　lower)　and　safer　inorganic　product　(isometric　IO3−)　than　UV/PS　with　similar　detoxification　effect.　©　2025