This　paper　studies　the　biomechanical　behaviors　of　a　red　blood　cell　(RBC)　by　nanoindentation　technique　and　finite　element　simulation.　The　Young＇s　modulus　and　load-displacement　curve　of　RBC　are　measured　by　nanoindentation.　Then　a　3D　finite　element　model　of　RBC　is　built　to　simulate　the　naoindentation　process.　The　load-displacement　curves　of　RBC　are　obtained　by　altering　friction　coefficients　between　the　tip　and　curvature　radius　of　the　tip.　It　is　shown　that　the　FEM　results　are　agreement　with　the　experimental　data　for　nanoindentation　of　RBC.　The　deformation　of　RBC　is　obviously　influenced　by　the　curvature　radius　of　the　tip　but　slightly　by　the　friction　coefficient　between　the　tip　and　the　cell.