In　this　paper,　4D-QSAR　analysis　base　on　LQTA-QSAR　method　and　MIA-QSAR　analysis　were　presented.　And　a　combination　model　of　4D-QSAR　model　and　MIA-QSAR　model　with　better　predictive　performance　was　built.　The　4D-QSAR　descriptors　were　obtained　by　calculating　the　interaction　energies　between　the　probes　and　aligned　conformational　ensemble　profiles　(CEP)　resulting　from　molecular　dynamics　simulation.　The　MIA　descriptors　were　generated　from　aligned　images　of　chemical　structure.　Those　descriptors　were　filtered　and　employed　in　partial　least　squares　(PLS)　regression.　The　combination　model　was　built　by　the　merging　the　descriptors　generated　by　the　two　methods　of　4D-QSAR　and　MIA-QSAR　analysis.　Those　models　were　built　using　programs　written　by　authors,　and　anyone　can　download　those　programs　at　https://github.com/masgils.　(C)　2019　Elsevier　Inc.　All　rights　reserved.