For　the　purpose　of　understanding　the　stress　distribution　in　the　sealing　rubber　and　the　metal　component　of　the　packer　and　optimization　based　on　the　analysis　results,　the　structures　are　analyzed　by　using　MARC　nonlinear　analysis　software.　The　effect　of　main　sizes　on　the　results　is　obtained　by　changing　the　sizes　and　re-analyzing　the　structures.　It　is　fitted　by　response　surface　method.　An　optimization　model　is　established　which　takes　the　maximum　principal　stress　of　the　sealing　rubber　and　the　maximum　Mises　stress　of　the　metal　component　of　the　packer　as　synthesis　objective.　The　model　is　subject　to　the　constraints　of　the　sizes.　It　is　solved　by　using　the　quadratic　programming　method.　The　maximum　principal　stress　of　the　optimized　sealing　rubber　is　only　32%　of　the　original　structures＇　one.　The　maximum　Mises　stress　of　the　metal　component　and　the　sealing　performance　of　the　packer　remain　almost　unchanging.