In　this　work,　we　propose　a　negative　differential　thermal　resistance　(NDTR)　system　using　a　nanoscale　sandwiched　fluid.　Non-equilibrium　molecular　dynamics　simulations　and　kinetic　theory　analyses　show　that　the　heat　flux　through　the　system　can　be　suppressed　and　even　prohibited　when　the　temperature　difference　across　the　system　becomes　sufficiently　high.　The　phenomenon　of　NDTR　is　caused　by　the　fluid　adsorption　on　the　solid　surface　at　the　cold　end,　which　reduces　the　number　density　of　the　free　fluid　molecules　and　increases　the　total　thermal　resistance　of　the　whole　system.　The　proposed　NDTR　system　provides　theoretical　insights　for　the　design　of　certain　thermal　devices.