The　MgO-doped　hexagonal　boron　nitride　(MgO-h-BN)　nanomaterials　were　designed　as　a　support　for　Palladium　(Pd)　catalysts　for　CO　oxidation　reaction.　The　catalytic　properties　of　Pd/MgO(5)-h-BN　catalyst　was　investigated　and　compared　with　Pd/h-BN　catalyst.　Transmission　electron　microscopy　(TEM)　results　suggested　that　the　PdO　nanoparticles　with　small　grain　sizes　(ca.　8　nm)　were　effectively　dispersed　on　the　surface　of　MgO,　and　the　MgO　were　deposited　on　the　h-BN　nanosheets　in　the　Pd/MgO(5)-h-BN　catalyst.　X-ray　diffraction　(XRD)　and　X-ray　photoelectron　spectroscopy　(XPS)　analyses　revealed　that　a　small　amount　of　Mg2+　embedded　into　the　B　vacancies　of　h-BN　nanosheets　in　the　Pd/MgO(5)-h-BN　catalyst.　More　significantly,　a　large　amount　of　adsorbed　oxygen　appeared　near　the　B　vacancies　of　Pd/MgO(5)-h-BN　catalyst.　The　experiments　outcomes　of　diffuse　reflectance　fourier　transform　spectra　analysis　of　CO　(CO-DRIFT)　indicated　that　the　carbonate/formate　species　were　easily　decomposed　to　CO2　on　the　Pd/MgO(5)-h-BN　catalyst　than　Pd/h-BN　catalyst,　which　might　be　a　reason　why　the　Pd/MgO(5)-h-BN　catalyst　had　high　CO　oxidation　activity.　According　to　above　analyses,　we　provide　a　new　insight　for　the　MgO-h-BN　nanomaterials　for　Pd　catalysts　for　application　in　CO　oxidation　reaction.