Resistant　hypertension　(RH)　is　a　major　healthcare　issue,　causing　cardiovascular　and　cerebrovascular　diseases.　In　recent　years,　radiofrequency　(RF)　ablation　to　renal　sympathetic　denervation　(RSD)　is　a　new　effective　method　for　the　treatment　of　RH.　However,　the　effect　of　RSD　on　renal　artery　blood　flow　still　need　further　research.　In　this　study,　Particle　Image　Velocimetry　(PIV)　experiment　and　RF　ablation　experiment　were　used　to　observe　the　blood　flow　states　in　three　conditions:　no　ablation　with　flow,　ablation　with　no　flow,　and　ablation　with　flow.　The　results　showed　that　when　the　blood　flow　was　1L/min　in　renal　artery　without　ablation,　it　was　uniform　laminar　flow.　When　the　blood　was　static　in　renal　artery　with　ablation,　there　was　eddy　around　the　ablation　catheter.　When　the　blood　flow　was　1L/min　in　renal　artery　with　ablation,　the　eddy　disappeared　and　the　blood　flow　was　uniform　laminar　flow.　Therefore,　when　the　renal　artery　blood　flow　is　1L/min,　there　will　be　no　thrombus　and　hemolysis　in　the　renal　artery　due　to　eddy　current　and　large　velocity　gradient,　which　preliminarily　verified　the　safety　of　the　RSD.　Keyword:　Resistant　hypertension;　Radiofrequency　ablation;　Flow　field;　PIVClinical　relevance　-　When　the　blood　flow　of　renal　artery　is　1L/min,　there　will　be　no　thrombus　and　hemolysis　in　renal　artery　due　to　eddy　current　and　large　velocity　gradient　during　the　operation　of　RF　ablation　to　renal　sympathetic　denervation.　©　2020　IEEE.