In　this　paper,　we　come　up　with　a　novel　speech　enhancement　method,　which　integrates　nonnegative　matrix　factorization　(NMF)　and　computational　auditory　scene　analysis　(CASA)　using　deep　neural　network　(DNN).　Firstly,　we　can　obtain　the　basis　matrices　of　speech　and　noise　respectively　via　NMF　and　get　the　ideal　ratio　mask　(IRM)　that　is　based　on　CASA　by　using　deep　neural　network.　Then,　a　linear　minimum　mean　square　error　(LMMSE)　filter　in　fast　Fourier　transform　(FFT)　domain　is　constructed　and　transformed　to　the　Gammatone　domain.　Finally,　an　integrated　Wiener-like　filter　is　obtained　by　combining　the　filter　of　NMF　with　the　mask　of　CASA.　By　comparing　with　NMF　and　CASA　methods,　the　experiments　present　the　superiority　of　the　proposed　method.　©　2018　IEEE.