Elimination　of　nitrogen　pollution　from　wastewater　containing　high-strength　nitrate　(NO3--N)　is　a　significant　issue　to　prevent　deterioration　of　water　quality　and　eutrophication　of　receiving　water　body.　Traditional　denitrification　process　faces　several　challenges　including　the　huge　organic　carbon　demand,　intermediate　products　accumulation,　and　long　acclimatization　period.　In　this　study,　an　efficient　solution　was　given　by　a　novel　two-stage　Partial　Denitrification　(PD)-Anammox　process.　High　NO3--N　(1000　mg　N/L)　wastewater　and　municipal　sewage　(COD:　182.5　mg/L,　ammonia　(NH4+-N):　58.3　mg/L)　were　simultaneously　introduced　to　the　PD　reactor　for　NO3--N　converting　to　NO2--N.　The　NH4+-N　and　NO2--N　in　effluent　of　PD　were　removed　in　subsequent　anammox　reactor.　Results　showed　that　a　satisfactory　nitrogen　removal　was　achieved　by　optimizing　the　volume　ratios　of　influent　NO3--N　and　municipal　sewage,　as　well　as　the　external　organic　matter　dosage.　The　NO3--N　removal　efficiency　reached　up　to　95.8%　without　accommodation　period,　along　with　the　NH4+-N　removal　achieving　92.8%.　Anammox　contributed　to　78.9%　of　TN　removal　despite　the　high　COD　(76.5-98.6　mg/L)　in　PD　effluent　was　introduced,　indicating　the　significant　stability　of　the　integrated　process.　The　microbial　analysis　suggested　that　the　Candidatus　Brocadia,　identified　as　anammox　bacteria,　cooperated　stable　with　denitrifying　bacteria　in　215-day　operation.　The　PD-Anammox　process　offers　an　economically　and　technically　attractive　approach　in　the　high　NO3--N　wastewater　treatment　since　it　has　great　advantages　of　much　low　carbon　demand,　minimal　sludge　production,　enabling　simultaneous　treatment　of　municipal　sewage,　and　avoiding　the　common　issues　in　traditional　denitrification　process.