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Author:

Peng, Kun (Peng, Kun.) | Cui, Xinyang (Cui, Xinyang.) | Qiao, Aike (Qiao, Aike.) (Scholars:乔爱科) | Mu, Yongliang (Mu, Yongliang.)

Indexed by:

EI Scopus SCIE PubMed

Abstract:

BackgroundBiodegradable stents display insufficient scaffold performance due to their poor Young's Modulus. In addition, the corresponding biodegradable materials harbor weakened structures during degradation processes. Consequently, such stents have not been extensively applied in clinical therapy. In this study, the scaffold performance of a patented stent and its ability to reshape damaged vessels during degradation process were evaluated.MethodsA common stent was chosen as a control to assess the mechanical behavior of the patented stent. Finite element analysis was used to simulate stent deployment into a 40% stenotic vessel. A material corrosion model involving uniform and stress corrosion was implemented within the finite element framework to update the stress state following degradation.ResultsThe results showed that radial recoiling ratio and mass loss ratio of the patented stent is 7.19% and 3.1%, respectively, which are definitely lower than those of the common stent with the corresponding values of 22.6% and 14.1%, respectively. Moreover, the patented stent displayed stronger scaffold performance in a corrosive environment and the plaque treated with patented stents had a larger and flatter lumen.ConclusionOwing to its improved mechanical performance, the novel biodegradable zinc alloy stent reported here has high potential as an alternative choice in surgery.

Keyword:

Biodegradable stent Stent design Corrosion Finite element analysis

Author Community:

  • [ 1 ] [Peng, Kun]Beijing Univ Technol, Coll Life Sci & Bioengn, 100 Pingleyuan, Beijing 100124, Peoples R China
  • [ 2 ] [Cui, Xinyang]Beijing Univ Technol, Coll Life Sci & Bioengn, 100 Pingleyuan, Beijing 100124, Peoples R China
  • [ 3 ] [Qiao, Aike]Beijing Univ Technol, Coll Life Sci & Bioengn, 100 Pingleyuan, Beijing 100124, Peoples R China
  • [ 4 ] [Mu, Yongliang]Northeastern Univ, Shenyang 110819, Liaoning, Peoples R China

Reprint Author's Address:

  • 乔爱科

    [Qiao, Aike]Beijing Univ Technol, Coll Life Sci & Bioengn, 100 Pingleyuan, Beijing 100124, Peoples R China

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Source :

BIOMEDICAL ENGINEERING ONLINE

ISSN: 1475-925X

Year: 2019

Volume: 18

3 . 9 0 0

JCR@2022

ESI Discipline: MOLECULAR BIOLOGY & GENETICS;

ESI HC Threshold:259

JCR Journal Grade:3

Cited Count:

WoS CC Cited Count: 6

SCOPUS Cited Count: 8

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 1

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