Rene　80　has　been　widely　used　in　aero-engine,　gas　turbines　and　other　high　temperature　applications　because　of　its　pronounced　combination　of　good　corrosion　resistance,　fatigue　resistance　and　excellent　mechanical　properties.　Laser　controlled　directional　solidification　is　always　considered　to　be　the　better　way　to　manufacture　and　repair　hot-section　components.　The　paper　focused　on　the　dendrite　growing　morphology　controlling　through　comprehensive　effect　of　laser　deposition　parameters　and　substrate　crystallographic　orientation.　With　same　parameters　elaborately　selected,　vertical　walls　were　built　up　by　familiar　laser　beam　scanning　pattern　and　different　substrate　crystallographic　orientation,　parallel　and　vertical　to　the　building　up　direction　of　vertical　wall,　respectively.　The　optical　micrographs　(OM)　and　Electron　backscatter　diffraction　(EBSD)　investigation　were　performed　mainly　on　the　transverse,　longitudinal　and　vertical　cross-section　of　both　vertical　walls　above　mentioned.　At　the　same　time　the　pole　figures　gave　the　misorientation　angle　of　the　vertical　wall　with　fast　identical　crystallographic　orientation.　＇　phase　precipitates　was　investigated　of　vertical　walls　by　SEM　image.　The　paper　reported　a　route　to　produce　full　directional　solidified　microstructure　with　different　substrate　crystallographic　orientation.