Reinforced　concrete　(RC)　frames　are　one　of　the　most　commonly　used　structural　systems　worldwide.　Earthquake　actions　and　progressive　collapse　caused　by　accidental　local　damage　are　two　critical　hazards　increasing　collapse　risks　of　multi-story　RC　frames.　A　significant　difference　is　well　recognized　between　the　structural　seismic　design　and　progressive　collapse　design.　Whilst　the　seismic　design　focuses　on　resisting　the　lateral　forces　due　to　earthquake,　the　progressive　collapse　design　deals　with　resisting　the　unbalanced　vertical　load　induced　by　a　localized　failure.　Existing　research　has　revealed　that　considering　the　two　different　designs　individually　for　a　structure　may　lead　to　an　undesirable　overall　structural　performance　and　unnecessary　waste　of　construction　materials.　In　this　study,　a　novel　Multi-Hazard　Resistant,　Prefabricated　Concrete　(MHRPC)　frame　system　is　proposed　to　satisfy　the　demands　of　both　structural　seismic　and　progressive　collapse　designs.　Cyclic　and　progressive　collapse　tests　are　conducted　to　validate　the　performance　of　this　newly　proposed　structural　system.　The　mechanisms　of　the　MHRPC　frame　system　under　both　cyclic　loads　and　a　middle　column　removal　scenario　are　analyzed　based　on　the　experimental　results　and　numerical　simulations　using　OpenSees.　The　results　indicate　that　the　proposed　fame　system　exhibits　such　characteristics　as　large　rotation,　low　damage,　self-centering,　and　ease　of　repair.　The　system　is　also　proven　to　be　able　to　meet　the　multi-hazard　design　requirements　of　RC　frames　against　both　earthquake　actions　and　progressive　collapse.