This　paper　presents　the　application　of　a　novel　structural　testing　method　involving　the　combined　use　of　shake　tables　and　computational　engines　for　the　seismic　simulation　of　soil-structure　interaction　(SSI)　under　multi-support　ground　input　motion.　The　structure　with　soil　to　be　simulated　is　divided　into　physical　and　numerical　substructures,　in　which　the　building　structure　is　seen　as　physical　substructures　and　soil　is　seen　as　numerical　substructures.　The　interface　reaction　between　the　physical　and　numerical　substructures　is　imposed　by　the　shake　table　as　ground　motion　and　the　resulting　acceleration　is　fed　back　to　the　computational　device.　The　unique　aspect　of　this　method　is　to　simulate　the　SSI　systems　subjected　to　multi-support　excitation.　Then　the　substructuring　strategy　and　the　control　performance　associated　with　the　real-time　substructuring　testing　for　SSI　were　performed.　Finally,　the　real-time　substructuring　experiments　for　a　frame　and　a　bridge　subjected　to　earthquake　excitation　were　implemented　to　verify　the　validity　of　the　substructure　testing　for　SSI.　©　2011　EUCENTRE.　All　rights　reserved.