Advancements　in　information　and　communication　systems　offer　immense　opportunities　for　supply　chain　intelligence　and　autonomy　establishing　stepping　stones　for　Industry　4.0　supply　chains　(SCs).　As　a　crucial　SC　decision,　sustainable　supplier　evaluation　and　selection　process　have　been　addressed　abundantly　in　the　previous　literature.　However,　this　process　has　not　yet　been　realized　within　Industry　4.0　SCs　where　interconnection,　real-time　information　transparency,　technical　assistance　and　decentralization　of　members　of　a　physical　system　(i.e.,　supply　chain　members)　are　regarded　as　the　main　design　principles.　To　narrow　the　identified　gap,　a　Multi-Agent　Systems　(MASs)　approach　is　proposed　for　addressing　sustainable　supplier　evaluation　and　selection　process　to　provide　a　proper　communication　channel,　structured　information　exchange　and　visibility　among　suppliers　and　manufacturers.　Furthermore,　the　application　of　MASs　in　this　process　and　their　natural　applicability　as　one　of　the　enabling　technologies　in　moving　towards　Industry　4.0　SCs　are　investigated　in　detail.　It　is　found　that　the　proposed　approach　can　help　decision-makers　inside　manufacturing　firms　to　make　prompt　decisions　with　less　human　interactions.　The　merit　of　the　developed　MAS　is　demonstrated　through　a　real-world　implementation　on　a　medical　device　manufacturer.　Finally,　the　limitations　and　advantages　of　the　proposed　approach　are　presented　together　with　some　remarks　for　future　work.