Highly　active　and　durable　electrocatalysts　are　vital　for　commercialization　of　direct　methanol　fuel　cells.　In　this　work,　a　three-dimensional　nanocomposite　consisting　of　platinum　nanoparticles,　W18O49　nanocables,　and　reduced　graphene　oxide　composite　(Pt/W18O49　NCs-rGO)　has　been　prepared　as　an　electrocatalyst　for　methanol　oxidation　reaction　(MOR).　The　catalyst　is　prepared　through　a　two-step　method.　The　W18O49　nanocables　and　the　reduced　graphene　oxide　composite　are　prepared　by　a　solvothermal　process.　Then,　Pt　nanoparticles　are　loaded　on　the　W18O49　nanocables　and　the　reduced　graphene　oxide　composite　by　a　hydrogen　reduction　at　ambient　condition.　The　obtained　catalyst　has　a　special　three-dimensional　architecture　consisting　of　two-dimensional　nanosheets,　assembled　one-dimensional　nanocables,　and　the　loaded　nanoparticles　on　their　surface.　The　Pt/W18O49　NCs-rGO　catalyst　shows　1.56　time　mass　activities　than　the　Pt/C,　with　the　current　density　of　the　forward　anodic　peak　reaching　1624　mA/mgPt　at　0.854　V　versus　reversible　hydrogen　electrode　potential　in　0.1　M　HClO4　and　0.5　M　CH3OH　mixed　electrolyte.　It　also　shows　a　strong　antipoisoning　property　toward　CO.　For　the　durability　testing,　the　current　density　of　Pt/W18O49　NCs-rGO　shows　a　37%　decay,　whereas　the　current　of　Pt/C　catalyst　shows　a　41%　degradation　from　600　to　3600　s　at　0.7　V.　The　high　activity　toward　MOR,　good　antipoisoning　for　intermediate　products,　and　excellent　stability　are　ascribed　to　strong　metal-support　interaction　effects　between　the　Pt　nanoparticles　and　the　W18O49　NCs.