Background:　Colon　cancer　is　one　of　the　most　common　cancers　and　it　is　the　fourth　leading　cause　of　cancer-related　deaths　worldwide.　YAP　can　promote　cell　proliferation　and　inhibit　apoptosis,　leading　to　loss　of　cell　contact　inhibition　and　promoting　malignant　cell　transformation.　Material/Methods:　In　this　study　we　analyzed　the　effects　of　different　curcumin　concentrations　on　the　proliferation　of　colon　cancer　cells　using　MTT　and　colony　formation　assays.　Western　blot　detection　was　performed　to　confirm　the　YAP,LC3-II,　and　P62　expression.　Results:　Curcumin　inhibited　proliferation　and　promoted　colon　cancer　cell　autophagy.　In　addition,　Western　blot　results　indicated　that　curcumin　suppressed　YAP　expression　in　colon　cancer　cells.　To　assess　the　mechanism,　we　treated　the　cell　lines　with　curcumin　and　assessed　YAP　overexpression　and　YAP　knockdown.　The　results　revealed　that　curcumin　inhibits　the　proliferation　and　promotes　autophagy　of　these　cell　lines.　Western　blot　results　showed　that　curcumin　reversed　the　effect　of　YAP　in　colon　cancer　cells.　Conclusions:　Our　results　suggest　that　YAP　has　great　promise　for　treatment　of　colon　cancer　and　that　it　might　be　a　potential　diagnostic　marker　for　colon　cancer.