Cell　lasers　is　a　frontier　interdisciplinary　research　field　of　laser　photonics　and　life　sciences,　the　principle　of　which　is　that,　under　the　optical　feedback　of　the　cavity,　the　weak　signal　can　be　oscillated　and　amplified　via　the　combination　of　fluorescent　protein,　bio-compatible　fluorescent　dye　and　lucifcrin　into　cells　in　the　fluidic　environment.　We　present　a　detailed　discussion　about　the　research　status　and　basic　principles　of　Fabry-Perot　cavity　and　whispering-gallery-mode　microcavity.　Laser-based　detection　can　effectively　enhance　the　sensitivity　and　resolution　compared　with　the　tradition　fluorescence-based　detection,　benefitting　from　the　feedback　amplification　of　cavity.　The　physiological　changes　inside　cells　arc　studied　with　the　analysis　of　the　spectra　and　modes　of　the　cell　laser　emission　simultaneously.　It　11　provide　new　technologies　and　design　ideas　for　medical　diagnosis,　three-dimensional　super-resolution　imaging　of　biomaterials　and　integrated　light　source　research.　©　2018　Laser　and　Optoelectronics　Progress.All　rights　reserved.