Although　venoarterial　extracorporeal　membrane　oxygenation　(VA-ECMO)　was　widely　used　in　clinical　practice,　the　effects　of　cardiac　output　on　the　aortic　oxygen　distribution　were　still　unclear.　Hence,　the　present　study　aims　to　evaluate　the　effect　of　cardiac　function　on　the　aortic　oxygen　distribution　under　VA-ECMO　support.　A　novel　model,　combining　computational　fluid　dynamics,　multiphase　fluid　approach,　and　oxygen　transport　theory　together,　was　established.　According　to　the　clinical　practice,　four　cardiac　output　conditions,　including　0,　1,　2,　and　2.5　L/min,　were　designed.　The　results　demonstrated　that　the　proposed　method　could　accurately　calculate　the　distribution　of　oxygen　in　the　aorta.　Moreover,　the　aortic　oxygen　distribution　was　significantly　regulated　by　the　local　blood　flow　pattern.　The　deoxygenated　blood　flow　and　oxygenated　blood　flow　met　at　the　aortic　arch　and　formed　the　so-called　oxygenshed　phenomenon.　Along　with　the　cardiac　output　increase,　the　oxygenshed　was　moved　from　the　proximal　of　the　aortic　arch　to　the　descending　aorta.　Meanwhile,　the　oxygen　contents　in　the　brachiocephalic　artery　and　left　common　carotid　artery　were　reduced　along　with　the　increase　of　cardiac　output.　The　study　could　provide　much　useful　information　on　the　oxygen　distribution　in　the　aorta　to　surgeons　and　operators　of　VA-ECMO.