Using　a　three-sludge　system　consisted　of　anaerobic/oxic(A/O)　process,　partial　nitritation　and　anaerobic　ammonium　oxidation(ANAMMOX)　reactors,　cost-effective　removal　of　nitrogen　and　phosphate　from　municipal　wastewater　was　achieved.　The　experimental　results　showed　that　effluent　total　phosphorus(TP)　of　the　A/O　system　was　less　than　0.5　mg/L　under　hydraulic　retention　time(HRT)　of　3.6　h.　Partial　nitritation　with　nitrite　accumulation　efficiency　of　75%-96%　was　realized　in　the　partial　nitritation　system　under　room　temperature,　DO　<　0.2　mg/L　and　HRT　of　4.6　h.　Under　temperature　of　27-30°C　and　HRT　of　1.4　h,　effluent　total　nitrogen(TN)　and　TN　removal　rate　of　ANAMMOX　reactor　were　less　than　8　mg/L　with　the　minimum　value　of　1.6　mg/L　and　0.57　kg/(m3　·　d),　respectively.　In　the　three-sludge　system,　phosphate　accumulating　organisms,　ammonia-oxidizing　bacteria　and　Anammox　bacteria　existed　under　suitably　environmental　condition　to　optimize　the　microbial　community　structure　and　improve　treatment　efficiency　of　various　units.　Autotrophic　nitrogen　removal　can　reduce　62.5%　of　the　oxygen　supply,　save　100%　of　denitrification　carbon　sources　theoretically,　lower　the　sludge　production,　and　greatly　decrease　carbon　dioxide　emission.　As　compared　to　traditional　biological　nutrient　removal　process,　the　three-sludge　system　has　great　advantages　and　potential　in　energy　saving　and　carbon　dioxide　emission　reduction　to　realize　sustainable　development　of　water　resources.