This　study　aimed　to　analyze　the　variations　in　groundwater　quality,　vulnerability　and　potential　health　risk　from　2006　to　2016　in　the　Limin　District,　Harbin,　China.　Groundwater　geochemical　characteristics　were　described　using　statistical　analysis　and　Piper　diagrams.　A　modified　DRASTIC　model　that　combined　factors　of　intrinsic　aquifer　vulnerability　and　land　use　was　applied　to　assess　groundwater　vulnerability.　The　weights　of　parameters　were　adjusted　by　using　the　analytic　hierarchy　process　(AHP)　to　optimize　the　model.　The　non-carcinogenic　health　risk　was　estimated　by　the　Unites　States　Environmental　Protection　Agency　(USEPA)　model.　Results　suggested　that　concentrations　of　NH4-N,　Fe　and　Mn　in　groundwater　exceeded　the　limits　both　in　2006　and　in　2016.　The　concentration　of　Fe　in　the　groundwater　showed　more　significant　variation　between　2006　and　2016　than　the　other　parameters.　Very　high　vulnerability　zones　increased　from　6.3%　in　2006　to　16.9%　in　2016,　and　distributed　on　agricultural　land,　indicating　that　agriculture　was　still　a　major　source　of　pollution.　Mn　and　NO3-N　contributed　the　most　to　human　health　risks　in　2006　and　2016,　respectively.　This　study　highlights　the　influence　of　groundwater　quality　variation　in　decadal　exploitation　on　human　health.