By　using　SBA-15　and　RF　latex　with　an　average　diameter　of　around　400　nm　as　dual　templates,　the　hollow　mesoporous　silica　spheres　(H-SBA15)　with　highly　ordered　parallel　pore　size　distribution　centered　at　3.8　nm　were　subsequently　synthesized　via　modified　Stober　method.　Meanwhile,　in　order　to　synthesis　radial　pore　size　distribution,　as　compared　with　that　of　H-SBA15,　hollow　mesoporous　silica　spheres　(H-BMMs)　were　synthesized　by　using　RF　latex　as　a　hard　template　and　cetyltrimethylammonium　bromide　as　a　soft　template.　The　effects　of　RF　additives　on　the　structural　properties　of　H-SBA15　and　H-BMMs　were　systematically　investigated　via　XRD,　N-2　sorption　isotherms,　SEM,　and　TEM　method.　It　was　found　that　their　tunable　shell　thickness　could　be　easily　controlled　from　35　to　75　nm,　particularly,　the　mesopores　structures　of　H-BMMs　were　effectively　tailored　by　adjusting　ammonia　dosage　during　sol-gel　process,　showing　a　decreasing　tendency　for　d　value　of　(100)　peak　and　gradual　disappearance　of　mesopores.　Their　drug-loading　and　releasing　performances　were　preliminary　investigated　using　ibuprofen　as　a　model　drug.