To　meet　the　continuously　increased　needs　for　seismic　damage　prediction,　refined　models　have　become　an　important　development　trend　in　urban　regional　seismic　damage　prediction.　However,　the　application　of　refined　models　is　limited　by　the　high　cost　of　computation　if　it　is　implemented　on　traditional　CPU　platform.　In　recent　years,　a　technology　with　powerful　parallel　computing　capability　and　lower　cost,　GPU　technology,　has　been　developed　and　applied　rapidly.　In　this　paper,　a　simulating　method　for　urban　regional　seismic　damage　that　can　significantly　reduce　the　computation　time,　was　developed　based　on　GPU-CPU　cooperative　computing　technology.　The　proposed　method　was　then　applied　to　the　seismic　damage　simulation　of　a　medium-sized　city　to　illustrate　the　unique　advantages　of　GPU　technology　in　large-scale　regional　seismic　damage　simulation.