A　fast,　feasible,　eco-friendly　method　for　determination　of　sulfonamides　using　in-tube　solid-phase　microextraction　(IT-SPME)　coupled　with　capillary　electrophoresis-laser　induced　fluorescence　was　developed.　The　graphene-embedded　porous　polymer　monolithic　column　prepared　via　in-situ　UV　polymerization　was　proposed　as　the　IT-SPME　column.　The　method　was　applied　to　determine　residual　sulfonamides　in　a　real　milk　sample,　and　an　amount　of　3.7　ng　mL(-1)　sulfamethazine　was　detected,　which　was　much　lower　than　the　maximum　residue　limit.