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Author:

Jing, Bin (Jing, Bin.) | Long, Zhuqing (Long, Zhuqing.) | Liu, Han (Liu, Han.) | Yan, Huagang (Yan, Huagang.) | Dong, Jianxin (Dong, Jianxin.) | Mo, Xiao (Mo, Xiao.) | Li, Dan (Li, Dan.) | Liu, Chunhong (Liu, Chunhong.) | Li, Haiyun (Li, Haiyun.)

Indexed by:

SSCI Scopus SCIE PubMed

Abstract:

Major depressive disorder (MDD) is a leading world-wide psychiatric disorder with high recurrence rate, therefore, it is desirable to identify current MDD (cMDD) and remitted MDD (rMDD) for their appropriate therapeutic interventions. In the study, 19 cMDD, 19 rMDD and 19 well-matched healthy controls (HC) were enrolled and scanned with the resting-state functional magnetic resonance imaging (rs-fMRI). The Hurst exponent (HE) of rs-fMRI in AAL-90 and AAL-1024 atlases were calculated and compared between groups. Then, a radial basis function (RBF) based support vector machine was proposed to identify every pair of the cMDD, rMDD and HC groups using the abnormal HE features, and a leave-one-out cross-validation was used to evaluate the classification performance. Applying the proposed method with AAL-1024 and AAL-90 atlas respectively, 87% and 84% subjects were correctly identified between cMDD and HC, 84% and 71% between rMDD and HC, and 89% and 74% between cMDD and rMDD. Our results indicated that the HE was an effective feature to distinguish cMDD and rMDD from HC, and the recognition performances with AAL-1024 parcellation were better than that with the conventional AAL-90 parcellation.

Keyword:

hurst exponent major depressive disorder support vector machine automated anatomical labeling (AAL) atlas resting-state fMRI

Author Community:

  • [ 1 ] [Jing, Bin]Capital Med Univ, Sch Biomed Engn, Beijing, Peoples R China
  • [ 2 ] [Long, Zhuqing]Capital Med Univ, Sch Biomed Engn, Beijing, Peoples R China
  • [ 3 ] [Liu, Han]Capital Med Univ, Sch Biomed Engn, Beijing, Peoples R China
  • [ 4 ] [Yan, Huagang]Capital Med Univ, Sch Biomed Engn, Beijing, Peoples R China
  • [ 5 ] [Dong, Jianxin]Capital Med Univ, Sch Biomed Engn, Beijing, Peoples R China
  • [ 6 ] [Mo, Xiao]Capital Med Univ, Sch Biomed Engn, Beijing, Peoples R China
  • [ 7 ] [Li, Haiyun]Capital Med Univ, Sch Biomed Engn, Beijing, Peoples R China
  • [ 8 ] [Li, Dan]Beijing Univ Technol, Sch Software Engn, Beijing, Peoples R China
  • [ 9 ] [Liu, Chunhong]Capital Med Univ, Beijing Hosp Tradit Chinese Med, Acupuncture & Moxibust Dept, Beijing, Peoples R China
  • [ 10 ] [Liu, Chunhong]Capital Med Univ, Beijing Anding Hosp, Dept Radiol, Beijing Key Lab Mental Disorders, Beijing, Peoples R China

Reprint Author's Address:

  • [Li, Haiyun]Capital Med Univ, Sch Biomed Engn, Beijing, Peoples R China

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Source :

ONCOTARGET

ISSN: 1949-2553

Year: 2017

Issue: 52

Volume: 8

Page: 90452-90464

ESI Discipline: MOLECULAR BIOLOGY & GENETICS;

ESI HC Threshold:309

Cited Count:

WoS CC Cited Count: 19

SCOPUS Cited Count: 21

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 9

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