Dielectric　microspheres　with　extraordinary　micro　scale　optical　properties,　such　as　photonic　nanojets,　optical　whispering-gallery　modes　(WGMs),　and　directional　antennas,　have　drawn　interest　in　many　research　fields.　Microsphere-enhanced　Raman　spectroscopy　(MERS)　is　an　alternative　approach　for　enhanced　Raman　detection　by　dielectric　microstructures.　Unfortunately,　fabrication　of　microsphere　monolayer　arrays　is　the　major　challenge　of　MERS　for　practical　applications　on　various　specimen　surfaces.　Here　we　report　a　microsphere-embedded　film　(MF)　by　immersing　a　highly　refractive　micro　sphere　monolayer　array　in　the　poly(dimethylsiloxane)　(PDMS)　film　as　a　flexible　MERS　sensing　platform　for　one-to　three-dimensional　(1D　to　3D)　specimen　surfaces.　The　directional　antennas　and　wave-guided　whispering-gallery　modes　(WG-WGMs)　contribute　to　the　majority　of　Raman　enhancement　by　the　MFs.　Moreover,　the　MF　can　be　coupled　with　surface-enhanced　Raman　spectroscopy　(SERS)　to　provide　an　extra　＞10-fold　enhancement.　The　limit　of　detection　is　therefore　improved　for　sensing　of　crystal　violet　(CV)　and　Sudan　I　molecules　in　aqueous　solutions　at　concentrations　down　to　10-7　M.　A　hybrid　dual-layer　microsphere　enhancer,　constructed　by　depositing　a　MF　onto　a　microsphere　monolayer　array,　is　also　demonstrated,　wherein　the　WG-WGMs　become　dominant　and　boost　the　enhancement　ratio　＞50-fold.　The　present　work　opens　up　new　opportunities　for　design　of　cost-effective　and　flexible　MERS　sensing　platforms　as　individual　or　associated　techniques　toward　practical　applications　in　ultrasensitive　Raman　detection.