The　unique　properties　of　polyoxometalates,　such　as　molecular　polarity,　redox　potential,　surface　charge　distribution,　shape　and　acidity,　influence　their　response　of　recognition　to　targeted　biological　macromolecules.　By　using　PM-19　(K7PTi2W10O40)　as　a　lead-compound,　a　series　of　novel　pyridinium　polyoxometalates　(A(7)PTi(2)W(10)O(40)),　which　hadn＇t　been　reported　in　literatures,　were　designed　and　synthesized.　The　evaluation　was　conducted　using　the　single-cycle　pseudovirus　infection　assay　(TZM-bl　assay),　CCK8　method　was　used　for　determining　the　cytotoxicity.　The　results　indicated　that　the　designed　pyridinium　polyoxometalates　had　a　lower　toxicity　to　TZM-bl　cells,　and　showed　higher　inhibitory　activity　against　HIV　1　virus.　(C)　2017　Published　by　Elsevier　Ltd.