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学者姓名：王娟
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Abstract ：
Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, Sal) is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, an environmental toxin that causes Parkinson's disease. However, the mechanism by which Sal mediates dopaminergic neuronal death remains unclear. In this study, we found that Sal significantly enhanced the global level of N-6-methyladenosine (m(6)A) RNA methylation in PC12 cells, mainly by inducing the downregulation of the expression of m(6)A demethylases fat mass and obesity-associated protein (FTO) and alkB homolog 5 (ALKBH5). RNA sequencing analysis showed that Sal downregulated the Hippo signaling pathway. The m(6)A reader YTH domain-containing family protein 2 (YTHDF2) promoted the degradation of m(6)A-containing Yes-associated protein 1 (YAP1) mRNA, which is a downstream key effector in the Hippo signaling pathway. Additionally, downregulation of YAP1 promoted autophagy, indicating that the mutual regulation between YAP1 and autophagy can lead to neurotoxicity. These findings reveal the role of Sal on m(6)A RNA methylation and suggest that Sal may act as an RNA methylation inducer mediating dopaminergic neuronal death through YAP1 and autophagy. Our results provide greater insights into the neurotoxic effects of catechol isoquinolines compared with other studies and may be a reference for assessing the involvement of RNA methylation in the pathogenesis of Parkinson's disease.
Keyword ：
YTHDF2 YTHDF2 FTO FTO salsolinol salsolinol RNA methylation RNA methylation YAP1 YAP1 Hippo pathway Hippo pathway autophagy autophagy ALKBH5 ALKBH5 m(6)A m(6)A Parkinson's disease Parkinson's disease
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| GB/T 7714 | Wang, Jianan , Ran, Yuanyuan , Li, Zihan et al. Salsolinol as an RNA m6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy [J]. | NEURAL REGENERATION RESEARCH , 2025 , 20 (3) : 887-899 . |
| MLA | Wang, Jianan et al. "Salsolinol as an RNA m6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy" . | NEURAL REGENERATION RESEARCH 20 . 3 (2025) : 887-899 . |
| APA | Wang, Jianan , Ran, Yuanyuan , Li, Zihan , Zhao, Tianyuan , Zhang, Fangfang , Wang, Juan et al. Salsolinol as an RNA m6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy . | NEURAL REGENERATION RESEARCH , 2025 , 20 (3) , 887-899 . |
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Abstract ：
SNARE is a crucial membrane fusion factor. It forms SNARE complex that play significant roles in regulating various biological functions. The SNARE protein family, including syntaxin13 (STX13), is highly conserved across various species, from yeast to humans. This review summarizes the molecular mechanisms by which STX13-associated SNARE complexes contribute to diverse endosome-mediated membrane fusions. Furthermore, multiple cofactors are essential for regulating the SNARE complexes-mediated membrane fusion. These include but are not limited to Rab GTPases and their effectors. The interaction of these factors with SNARE proteins constitutes a critical component driving vesicle fusion processes.
Keyword ：
Syntaxin13 Syntaxin13 SNARE SNARE Endosome Endosome
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| GB/T 7714 | Zhang, Wenting , Zhang, Haolin , He, Tianlong et al. The diverse functions of syntaxin 13 in endosome-mediated membrane fusion [J]. | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2025 , 307 . |
| MLA | Zhang, Wenting et al. "The diverse functions of syntaxin 13 in endosome-mediated membrane fusion" . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 307 (2025) . |
| APA | Zhang, Wenting , Zhang, Haolin , He, Tianlong , Li, Xianghua , Liu, Yukun , Han, Huijie et al. The diverse functions of syntaxin 13 in endosome-mediated membrane fusion . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2025 , 307 . |
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Abstract ：
ATG9A is a transmembrane protein essential for macroautophagy/autophagy that drives autophagosome formation by delivering essential proteins and lipids to the phagophore through vesicle trafficking. Here, we demonstrate that the atypical Rho GTPase RHOD is required for ATG9A trafficking and stimulates autophagosome formation. Upon starvation, RHOD interacted with ATG9A and accompanied ATG9A trafficking from the Golgi toward phagophores. In addition, starvation-induced high levels of RHOD resulted in Golgi fragmentation to further promote ATG9A vesicle export from the trans-Golgi network to the peripheral region. Loss of RHOD suppressed ATG9A trafficking and reduced the distribution of ATG9A on the phagophore. Moreover, WHAMM (WASP homolog associated with actin, golgi membranes and microtubules) forms a complex with RHOD and participates in this process in a RHOD-dependent manner. Importantly, RHOD mutants, which lack the exon II-containing effector region motif that is required for ATG9A binding or lack the CAAX box that is responsible for membrane targeting, fail to stimulate ATG9A trafficking and autophagosome formation. Furthermore, RHOD plays a distinct suppressor role in tumor development, partly associated with its regulatory effect on autophagy. These findings reveal the important roles of RHOD in autophagy and tumor development.Abbreviation: ATG9A: autophagy related 9A; BafA1: bafilomycin A1; BiFC: bimolecular fluorescence complementation; co-IP: co-immunoprecipitation; EBSS: Earle's balanced salt solution; FM: full culture medium; KO: knockout; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; PUP-IT: pupylation-based interaction tagging; RHOD: ras homolog family member D; SQSTM1: sequestosome 1; TGN: trans-Golgi network; VC: Venus C-terminal; VN: Venus N-terminal; WHAMM: WASP homolog associated with actin, golgi membranes and microtubules; WIPI2: WD repeat domain, phosphoinositide interacting 2; WT: wild-type; 3-MA: phosphatidylinositol 3-kinase (PtdIns3K) inhibitor 3-methyladenine.
Keyword ：
vesicle trafficking vesicle trafficking WHAMM WHAMM autophagy autophagy RHOD RHOD ATG9A ATG9A lung cancer lung cancer
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| GB/T 7714 | Wang, Sijia , Ren, Jing , Chi, Jinghan et al. RHOD mediates ATG9A trafficking to promote autophagosome formation during autophagy in cancer [J]. | AUTOPHAGY , 2025 . |
| MLA | Wang, Sijia et al. "RHOD mediates ATG9A trafficking to promote autophagosome formation during autophagy in cancer" . | AUTOPHAGY (2025) . |
| APA | Wang, Sijia , Ren, Jing , Chi, Jinghan , Guan, Yifei , Zheng, Ran , Wang, Juan et al. RHOD mediates ATG9A trafficking to promote autophagosome formation during autophagy in cancer . | AUTOPHAGY , 2025 . |
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Abstract ：
Unconventional protein secretion (UcPS) encompasses diverse non-canonical cellular export mechanisms that operate independently of the classical secretory pathway, representing a crucial cellular response to various physiological and pathological conditions. This comprehensive review synthesizes current understanding of UcPS mechanisms, particularly focusing on their roles in disease pathogenesis and progression. Recent advances in proteomics and cellular biology have revealed that UcPS facilitates the secretion of various biomedically significant proteins, including inflammatory mediators, growth factors, and disease-associated proteins, through multiple pathways such as membrane translocation, secretory lysosomes, and membrane-bound organelles. Notably, dysregulation of UcPS mechanisms has been implicated in various pathological conditions, including chronic inflammation, neurodegenerative disorders, and malignant transformation. We critically evaluate the molecular machinery governing UcPS, its regulation under cellular stress, and its contribution to disease mechanisms. Furthermore, we examine emerging therapeutic strategies targeting UcPS pathways, highlighting both opportunities and challenges in developing novel interventional approaches.
Keyword ：
Inflammation Inflammation Neurodegenerative diseases Neurodegenerative diseases Unconventional protein secretion Unconventional protein secretion Cancer Cancer
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| GB/T 7714 | Liu, Yukun , Zhang, Haolin , Li, Xianghua et al. Molecular mechanisms and pathological implications of unconventional protein secretion in human disease: from cellular stress to therapeutic targeting [J]. | MOLECULAR BIOLOGY REPORTS , 2025 , 52 (1) . |
| MLA | Liu, Yukun et al. "Molecular mechanisms and pathological implications of unconventional protein secretion in human disease: from cellular stress to therapeutic targeting" . | MOLECULAR BIOLOGY REPORTS 52 . 1 (2025) . |
| APA | Liu, Yukun , Zhang, Haolin , Li, Xianghua , He, Tianlong , Zhang, Wenting , Ji, Cuicui et al. Molecular mechanisms and pathological implications of unconventional protein secretion in human disease: from cellular stress to therapeutic targeting . | MOLECULAR BIOLOGY REPORTS , 2025 , 52 (1) . |
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Abstract ：
Macroautophagy involves the encapsulation of cellular components within double-membrane autophagosomes for subsequent degradation in vacuoles or lysosomes. Coat protein complex II (COPII) vesicles serve as a membrane source for autophagosome formation. However, the specific role of SEC24D, an isoform of the COPII coat protein SEC24, in the macroautophagy pathway remains unclear. In this study, we demonstrate that SEC24D is indispensable for macroautophagy and important for autophagosome closure. Depletion of SEC24D leads to the accumulation of unsealed isolation membranes. Furthermore, under conditions of starvation, SEC24D interacts with casein kinase1 delta (CK1 delta), a member of the casein kinase 1 family, and autophagy-related 9A (ATG9A). Collectively, our findings unveil the indispensable role of SEC24D in starvation-induced autophagy in mammalian cells.
Keyword ：
isolation membrane isolation membrane autophagosome closure autophagosome closure COPII COPII SEC24D SEC24D autophagy autophagy
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| GB/T 7714 | He, Tianlong , Ji, Cuicui , Zhang, Wenting et al. The COPII coat protein SEC24D is required for autophagosome closure in mammals [J]. | FEBS LETTERS , 2024 , 598 (23) : 2897-2909 . |
| MLA | He, Tianlong et al. "The COPII coat protein SEC24D is required for autophagosome closure in mammals" . | FEBS LETTERS 598 . 23 (2024) : 2897-2909 . |
| APA | He, Tianlong , Ji, Cuicui , Zhang, Wenting , Li, Xianghua , Liu, Yukun , Wang, Xiaoli et al. The COPII coat protein SEC24D is required for autophagosome closure in mammals . | FEBS LETTERS , 2024 , 598 (23) , 2897-2909 . |
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Abstract ：
Hrr25是酿酒酵母中Ⅰ型酪蛋白激酶家族成员，具有丝氨酸/苏氨酸蛋白激酶活性。其可以通过磷酸化多种蛋白质来发挥作用。Hrr25的底物蛋白质包括自噬相关蛋白、COPⅡ(coat protein complexes Ⅱ)囊泡衣被蛋白Sec24和Sec23、真核翻译起始因子6、γ-微管蛋白Tub4、延长器复合蛋白1等。另外Hrr25还可以与减数分裂重组蛋白Rec8、核孔蛋白Nup53、转录调节因子Crz1、转录激活因子Haa1等相互作用。Hrr25的多种相互作用蛋白质使其在自噬、囊泡运输、微管组装、减数分裂、有丝分裂、DNA修复、核糖体生物发生和弱有机酸胁迫途径等多种生物过程发挥作用。为了更好地了解Hrr25在各个生物过程中的作用机制以及各个生物过程之间的联系，本文总结了Hrr25的生物学功能及其作用机制，并概述其研究的潜在意义，为Hrr25的进一步研究提供理论依据。
Keyword ：
细胞分裂 细胞分裂 Hrr25 Hrr25 酿酒酵母 酿酒酵母 囊泡运输 囊泡运输
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| GB/T 7714 | 姜文艳 , 张文婷 , 王娟 . Ⅰ型酪蛋白激酶Hrr25的生物学功能和作用机制 [J]. | 中国生物化学与分子生物学报 , 2023 , 39 (08) : 1079-1086 . |
| MLA | 姜文艳 et al. "Ⅰ型酪蛋白激酶Hrr25的生物学功能和作用机制" . | 中国生物化学与分子生物学报 39 . 08 (2023) : 1079-1086 . |
| APA | 姜文艳 , 张文婷 , 王娟 . Ⅰ型酪蛋白激酶Hrr25的生物学功能和作用机制 . | 中国生物化学与分子生物学报 , 2023 , 39 (08) , 1079-1086 . |
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Abstract ：
服务业的扩大对外开放已成为中国构建新发展格局的重要一环。服务业的快速扩张和高水平对外开放，不仅为中国带来了经济繁荣，也是适应新发展阶段和应对全球经贸变革的重要举措。目前，中国存在服务业对外开放度较低及制度性障碍等问题。本文对中国服务业开放度测算的结果表明，现阶段中国服务业开放度远低于世界平均水平。基于此，本文提出了中国服务业开放度的提升路径，即利用区域协定深度参与国际合作、推动服务业体制改革、推行服务行业有序开放、调动基层政府促进开放积极性和建立服务型企业开放平台等。
Keyword ：
测算 测算 服务业 服务业 困境 困境 对外开放度 对外开放度 路径 路径
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| GB/T 7714 | 王娟 , 耿琳 . 中国服务业对外开放水平与提升路径研究 [J]. | 中国物价 , 2023 , PageCount-页数: 4 (11) : 11-13,20 . |
| MLA | 王娟 et al. "中国服务业对外开放水平与提升路径研究" . | 中国物价 PageCount-页数: 4 . 11 (2023) : 11-13,20 . |
| APA | 王娟 , 耿琳 . 中国服务业对外开放水平与提升路径研究 . | 中国物价 , 2023 , PageCount-页数: 4 (11) , 11-13,20 . |
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Abstract ：
Aloperine is an alkaloid found in the seeds and leaves of the medicinal plant Sophora alopecuroides L. It has been used as herbal medicine in China for centuries due to its potent anti-inflammatory, antioxidant, antibacterial, and antiviral properties. Recently, aloperine has been widely investigated for its therapeutic activities. Aloperine is proven to be an effective therapeutic agent against many human pathological conditions, including cancer, viral diseases, and cardiovascular and inflammatory disorders. Aloperine is reported to exert therapeutic effects through triggering various biological processes, including cell cycle arrest, apoptosis, autophagy, suppressing cell migration, and invasion. It has also been found to be associated with the modulation of various signaling pathways in different diseases. In this review, we summarize the most recent knowledge on the modulatory effects of aloperine on various critical biological processes and signaling mechanisms, including the PI3K, Akt, NF-kappa B, Ras, and Nrf2 pathways. These data demonstrate that aloperine is a promising therapeutic candidate. Being a potent modulator of signaling mechanisms, aloperine can be employed in clinical settings to treat various human disorders in the future.
Keyword ：
autophagy autophagy Ras Ras PI3K/Akt PI3K/Akt cell cycle cell cycle Nrf2 Nrf2 NF-kappa B NF-kappa B apoptosis apoptosis
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| GB/T 7714 | Tahir, Muhammad , Ali, Sakhawat , Zhang, Wenting et al. Aloperine: A Potent Modulator of Crucial Biological Mechanisms in Multiple Diseases [J]. | BIOMEDICINES , 2022 , 10 (4) . |
| MLA | Tahir, Muhammad et al. "Aloperine: A Potent Modulator of Crucial Biological Mechanisms in Multiple Diseases" . | BIOMEDICINES 10 . 4 (2022) . |
| APA | Tahir, Muhammad , Ali, Sakhawat , Zhang, Wenting , Lv, Boqiang , Qiu, Wenge , Wang, Juan . Aloperine: A Potent Modulator of Crucial Biological Mechanisms in Multiple Diseases . | BIOMEDICINES , 2022 , 10 (4) . |
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Abstract ：
Autophagy is an evolutionarily conserved pathway, in which cytoplasmic components are sequestered within double-membrane vesicles called autophagosomes and then transported into lysosomes or vacuoles for degradation. Over 40 conserved autophagy-related (ATG) genes define the core machinery for the five processes of autophagy: initiation, nucleation, elongation, closure, and fusion. In this review, we focus on one of the least well-characterized events in autophagy, namely the closure of the isolation membrane/phagophore to form the sealed autophagosome. This process is tightly regulated by ESCRT machinery, ATG proteins, Rab GTPase and Rab-related proteins, SNAREs, sphingomyelin, and calcium. We summarize recent progress in the regulation of autophagosome closure and discuss the key questions remaining to be addressed.
Keyword ：
closure closure isolation membrane isolation membrane autophagosome autophagosome autophagy autophagy
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| GB/T 7714 | Jiang, Wenyan , Chen, Xuechai , Ji, Cuicui et al. Key Regulators of Autophagosome Closure [J]. | CELLS , 2021 , 10 (11) . |
| MLA | Jiang, Wenyan et al. "Key Regulators of Autophagosome Closure" . | CELLS 10 . 11 (2021) . |
| APA | Jiang, Wenyan , Chen, Xuechai , Ji, Cuicui , Zhang, Wenting , Song, Jianing , Li, Jie et al. Key Regulators of Autophagosome Closure . | CELLS , 2021 , 10 (11) . |
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Abstract ：
To obtain new anticancer agents with antimetastatic adjunct efficacy, a series of novel N-4-hydrazone derivatives of 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one were designed and synthesized by an eight-step reaction, with appropriate yields. All the synthesized compounds were evaluated for their antiproliferative activity against A549 and MCF-7 cells and for antiplatelet aggregation activity in vitro. The results showed that compounds 25 and 35 not only showed potent antiproliferative activity against the A549 (IC50 = 15.3 and 21.4 mu M) and MCF-7 (IC50 = 15.6 and 10.9 mu M) cell lines but also showed certain antiplatelet aggregation activity (inhibition rates: 47.0% and 45.8%). These results indicated that the structural modification on the N-4-hydrazone moiety of 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one is promising to obtain novel anticancer compounds with antimetastatic adjunct efficacy. In addition, a molecular docking study was performed to investigate the possible targets, and these results indicated that compounds 25 and 35 have the potential to target EGFR, HER2, and P2Y(12).
Keyword ：
antimetastatic antimetastatic 3-d]pyrimidin-6-one 3-d]pyrimidin-6-one anticancer anticancer synthesis synthesis hydrazone hydrazone pyrrolo[2 pyrrolo[2
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| GB/T 7714 | Zhao, Zhichang , Wang, Hongjun , Tian, Nana et al. Synthesis and biological evaluation of N-4-hydrazone derivatives of 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one as novel anticancer agents with antimetastatic adjunct efficacy [J]. | ARCHIV DER PHARMAZIE , 2021 , 354 (11) . |
| MLA | Zhao, Zhichang et al. "Synthesis and biological evaluation of N-4-hydrazone derivatives of 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one as novel anticancer agents with antimetastatic adjunct efficacy" . | ARCHIV DER PHARMAZIE 354 . 11 (2021) . |
| APA | Zhao, Zhichang , Wang, Hongjun , Tian, Nana , Yan, Hong , Wang, Juan . Synthesis and biological evaluation of N-4-hydrazone derivatives of 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one as novel anticancer agents with antimetastatic adjunct efficacy . | ARCHIV DER PHARMAZIE , 2021 , 354 (11) . |
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