Query：
学者姓名：高靓
Refining：
Year
Type
Indexed by
Source
Complex
Co-Author
Language
Clean All
Abstract ：
Metal nanoclusters (NCs), comprising tens to hundreds of metal atoms, are condensed matter with concrete molecular structures and discrete energy levels. Compared to metal atoms and nanoparticles, metal NCs exhibit unique physicochemical properties, especially fascinating electrocatalytic activities. This review focuses on recent progress in the precise synthesis of metal NCs and their applications in electrochemical analysis of various disease biomarkers. First, we provide a brief overview of current nanotechnology-enabled electrochemical biosensors. Subsequently, we highlight the precise synthesis of metal NCs protected by various ligands such as peptides, proteins and nucleic acids. Next, we summarize the design and construction of electrochemical biosensors that utilize metal NCs as electrode materials to detect electrochemically active and inactive disease-associated biomarkers, including small biomolecules (glucose, reactive oxygen species, cholesterol, neurotransmitters and amino acids) and biomacromolecules (proteins, enzymes, and nucleic acids). Due to unique electrocatalytic properties, high specific surface areas, and atomically modulated structures, metal NCs promote electron exchange or act as a redox medium in these electrochemical sensing platforms. Finally, we conclude with present challenges and propose future research directions, with the aim to enhance the specificity, sensitivity, and durability of customized metal NC-based electrochemical biosensors for precise disease diagnostics.
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Han, Ying , Zhang, Ping , Duan, Xiaoyi et al. Advances in precise synthesis of metal nanoclusters and their applications in electrochemical biosensing of disease biomarkers [J]. | NANOSCALE , 2024 , 17 (7) : 3616-3634 . |
| MLA | Han, Ying et al. "Advances in precise synthesis of metal nanoclusters and their applications in electrochemical biosensing of disease biomarkers" . | NANOSCALE 17 . 7 (2024) : 3616-3634 . |
| APA | Han, Ying , Zhang, Ping , Duan, Xiaoyi , Gao, Xueyun , Gao, Liang . Advances in precise synthesis of metal nanoclusters and their applications in electrochemical biosensing of disease biomarkers . | NANOSCALE , 2024 , 17 (7) , 3616-3634 . |
| Export to | NoteExpress RIS BibTex |
Abstract ：
Programmed cell death ligand 1 (PD-L1)/programmed cell death protein 1 (PD-1) checkpoint inhibitor-based immunotherapy has provided a unique and potent weapon against cancer in clinical practice. The likelihood of achieving beneficial effects from PD-L1/PD-1 immune checkpoint blockade (ICB) therapy is clinically assessed by detecting PD-L1 expression through invasive tissue biopsies. However, PD-L1 expression is susceptible to tumor heterogeneity and dynamic response to ICB therapy. Moreover, currently, anti-PD-L1 immunotherapy still faces challenges of the low targeting efficiency of antibody drugs and the risk of immune-associated adverse events. To overcome these issues, advanced nanotechnology has been developed for the purpose of quantitative, non-invasive, and dynamic analyses of PD-L1, and to enhance the efficiency of ICB therapy. In this review, we first introduce the nanoprobe-assisted in vitro/in vivo modalities for the selective and sensitive analysis of PD-L1 during the diagnostic and therapeutic process. On the other hand, the feasibility of fabricating diverse functional nanocarriers as smart delivery systems for precisely targeted delivery of PD-L1 immune checkpoint inhibitors and combined therapies is highlighted. Finally, the current challenges are discussed and future perspectives for PD-L1-targeted cancer theranostics in preclinical research and clinical settings are proposed. Advanced nanotechnology developed for PD-L1 detection and PD-L1/PD-1 immune checkpoint-relevant combined cancer therapies is reviewed.
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Gao, Xinxin , Cao, Kai , Yang, Jingru et al. Recent advances in nanotechnology for programmed death ligand 1-targeted cancer theranostics [J]. | JOURNAL OF MATERIALS CHEMISTRY B , 2024 , 12 (13) : 3191-3208 . |
| MLA | Gao, Xinxin et al. "Recent advances in nanotechnology for programmed death ligand 1-targeted cancer theranostics" . | JOURNAL OF MATERIALS CHEMISTRY B 12 . 13 (2024) : 3191-3208 . |
| APA | Gao, Xinxin , Cao, Kai , Yang, Jingru , Liu, Linhong , Gao, Liang . Recent advances in nanotechnology for programmed death ligand 1-targeted cancer theranostics . | JOURNAL OF MATERIALS CHEMISTRY B , 2024 , 12 (13) , 3191-3208 . |
| Export to | NoteExpress RIS BibTex |
Abstract ：
Identifying effective reversal agents overcoming multidrug resistance with causal mechanisms from an efflux pump protein is of vital importance for enhanced tumor chemotherapy in clinic. To achieve this end, we construct a metal cluster-based probe, named clusterbody, to develop flow sorting-assisted single-cell mass spectrometry analysis. This clusterbody synthesized by biomimetic mineralization possesses an antibody-like property to selectively recognize an efflux pump protein. The intrinsic red fluorescence emission of the clusterbody facilitates fluorescence-activated high-throughput cell sorting of subpopulations with different multidrug resistance levels. Furthermore, based on the accurate formula of the clusterbody, the corresponding protein abundance at the single-cell level is determined through detecting gold content via precise signal amplification by laser ablation inductively coupled plasma mass spectrometry. Therefore, the effect of reversal agent treatment overcoming multidrug resistance is evaluated in a quantitative manner. This work opens a new avenue to identify reversal agents, shedding light on developing combined or synergetic tumor therapy.
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Li, Han , Li, Jiaojiao , Wang, Meng et al. Clusterbody Enables Flow Sorting-Assisted Single-Cell Mass Spectrometry Analysis for Identifying Reversal Agent of Chemoresistance [J]. | ANALYTICAL CHEMISTRY , 2022 , 95 (2) : 560-564 . |
| MLA | Li, Han et al. "Clusterbody Enables Flow Sorting-Assisted Single-Cell Mass Spectrometry Analysis for Identifying Reversal Agent of Chemoresistance" . | ANALYTICAL CHEMISTRY 95 . 2 (2022) : 560-564 . |
| APA | Li, Han , Li, Jiaojiao , Wang, Meng , Feng, Weiyue , Gao, Fuping , Han, Ying et al. Clusterbody Enables Flow Sorting-Assisted Single-Cell Mass Spectrometry Analysis for Identifying Reversal Agent of Chemoresistance . | ANALYTICAL CHEMISTRY , 2022 , 95 (2) , 560-564 . |
| Export to | NoteExpress RIS BibTex |
Export
| Results： |
Selected to |
| Format： |
