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学者姓名：苏冬冬
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Abstract ：
Acute lung injury (ALI) is one of the most common and highly prevailing respiratory system diseases. However, there is still a lack of effective specialized medicines for the treatment of ALI. Biocompatible gold nanoclusters (AuNCs) have shown great potential in alleviating ALI, but their lung-targeted delivery needs to be enhanced. In recent years, lipid nanoparticles (LNPs) have become the most promising delivery system for clinical application and achieved great success in mRNA vaccines during the COVID-19 pandemic. Herein, we constructed a lung-delivery formulation of AuNCs by encapsulating glutathione-coated gold nanoclusters (GA) in lung-delivery ionizable lipid nanoparticles (iLNPs) and termed it as GA@iLNP. Results indicated that GA@iLNP can promote the cellular uptake of GA and enhance the anti-inflammation efficiency in stimulated macrophages in vitro. In addition, iLNP encapsulation significantly increased the lung accumulation of GA in lipopolysaccharide (LPS)-induced ALI mice after intravenous injection and enhanced the alleviations of inflammation and tissue damage in the lungs. These results suggest that organ-selective iLNPs may be an ideal targeted delivery system for AuNCs, providing a powerful tool for translational applications of bioactive AuNCs.
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| GB/T 7714 | Bian, Yongning , Li, Yanggege , Xia, Dongfang et al. Ionizable lipid nanoparticles enhance lung delivery of gold nanoclusters for improving acute lung injury alleviation [J]. | NANOSCALE , 2025 , 17 (13) : 7888-7897 . |
| MLA | Bian, Yongning et al. "Ionizable lipid nanoparticles enhance lung delivery of gold nanoclusters for improving acute lung injury alleviation" . | NANOSCALE 17 . 13 (2025) : 7888-7897 . |
| APA | Bian, Yongning , Li, Yanggege , Xia, Dongfang , Huang, Yuanyu , Gao, Xueyun , Su, Dongdong et al. Ionizable lipid nanoparticles enhance lung delivery of gold nanoclusters for improving acute lung injury alleviation . | NANOSCALE , 2025 , 17 (13) , 7888-7897 . |
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Abstract ：
Zn2+ is one of the most critical micronutrients involved in embryonic development and growth. In situ tracking of the metabolic distribution of Zn2+ during embryogenesis can help to understand its role. However, the lack of practical fluorescence imaging tools hinders the dynamic tracking of Zn2+ changes and distribution in vivo. Here, we report a fluorogenic sensor BDA-1 based on BODIPY fluorophore, which can continuously monitor the changes and distribution of Zn2+ and achieve fluorescence mapping of labile Zn2+ in different organs during zebrafish embryonic development. The sensor BDA-1 itself exists as a tautomer and exhibits non-fluorescence due to the photo-induced electron transfer (PeT) process, while after specific binding to Zn2+, the product no longer exists as a tautomer and the fluorescence is significantly enhanced. The reversible behavior of fluores-cence can be demonstrated in living cells and zebrafish. Furthermore, BDA-1 successfully mapped the distri-bution and changes of Zn2+ at key stages of embryonic development. The sensor is expected to serve as a powerful tool to study Zn2+-related biological processes and promote the understanding of Zn2+ functions in the course of embryonic development.
Keyword ：
Embryogenesis mapping Embryogenesis mapping Imaging in vivo Imaging in vivo Reversibility Reversibility LabileZn2+ LabileZn2+ Fluorogenic sensor Fluorogenic sensor
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| GB/T 7714 | Chen, Xueqian , Niu, Wenchao , Yuan, Qing et al. Mapping the endogenous Zn2+ in situ during zebrafish embryogenesis by a fluorogenic sensor [J]. | SENSORS AND ACTUATORS B-CHEMICAL , 2023 , 376 . |
| MLA | Chen, Xueqian et al. "Mapping the endogenous Zn2+ in situ during zebrafish embryogenesis by a fluorogenic sensor" . | SENSORS AND ACTUATORS B-CHEMICAL 376 (2023) . |
| APA | Chen, Xueqian , Niu, Wenchao , Yuan, Qing , Zhang, Yong , Gao, Xueyun , Su, Dongdong . Mapping the endogenous Zn2+ in situ during zebrafish embryogenesis by a fluorogenic sensor . | SENSORS AND ACTUATORS B-CHEMICAL , 2023 , 376 . |
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Abstract ：
Hydrogen sulfide (H2S) is a gaseous signaling molecule that plays an important role in regulating various physiological activities in biological systems. As the fundamental structural and functional unit of organisms, cells are closely related to the homeostasis of their internal environment. The levels of H2S in different organelles maintain a certain balance, and any disruption of this balance will lead to various functional abnormalities that affect the health of organisms. Fluorescent imaging technology provides unique merits, such as simplicity, non-invasiveness, and real-time monitoring, and has become a powerful approach for the detection of molecules in biological systems. Based on the special physicochemical properties of H2S, numerous H2S-specific fluorogenic probes have been designed with different recognition mechanisms that enable rapid and accurate detection of H2S in cells. Therefore, this review briefly illustrates the design strategies, response principles, and biological applications of H2S-specific fluorescent probes and aims to provide relevant researchers with insight for future research.
Keyword ：
fluorescent probe fluorescent probe hydrogen sulfide (H2S) hydrogen sulfide (H2S) cell imaging cell imaging
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| GB/T 7714 | Liang, Weier , Zhang, Yong , Xiong, Shaoqing et al. Recent Progress in Fluorescent Probes for the Detection and Research of Hydrogen Sulfide in Cells [J]. | CHEMOSENSORS , 2023 , 11 (6) . |
| MLA | Liang, Weier et al. "Recent Progress in Fluorescent Probes for the Detection and Research of Hydrogen Sulfide in Cells" . | CHEMOSENSORS 11 . 6 (2023) . |
| APA | Liang, Weier , Zhang, Yong , Xiong, Shaoqing , Su, Dongdong . Recent Progress in Fluorescent Probes for the Detection and Research of Hydrogen Sulfide in Cells . | CHEMOSENSORS , 2023 , 11 (6) . |
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Abstract ：
Glioblastoma (GBM) is the most aggressive primary brain tumor with poor prognosis and high recurrence rate. The presence of the blood-brain barrier (BBB) prevents diagnostic and therapeutic drugs from penetrating and working in GBM. In traditional surgical treatment, it is difficult to completely distinguish the boundary between tumor and surrounding normal tissue, resulting in incomplete resection of tumor. Therefore, the diagnosis and treatment of GBM are very challenging. Several molecular probes and nanoprobes have been reported to successfully penetrate the BBB, selectively target and accumulate in GBM to achieve in situ imaging of brain tumors, thus achieving accurate diagnosis and treatment of orthotopic or non-orthotopic GBM. This paper reviews the advances of molecular probes and nanoprobes in image-guided diagnosis and treatment of GBM. The design principle, application, and advantages of each probe are enumerated in detail. Finally, the prospects and potential challenges of probes in the diagnosis and treatment of GBM are discussed with a view to further promote the study and application of novel imaging probes in GBM.
Keyword ：
therapy therapy glioblastoma glioblastoma image-guided image-guided optical imaging optical imaging diagnosis diagnosis
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| GB/T 7714 | Bian, Yongning , Wang, Yaling , Chen, Xueqian et al. Image-guided diagnosis and treatment of glioblastoma [J]. | VIEW , 2023 , 4 (3) . |
| MLA | Bian, Yongning et al. "Image-guided diagnosis and treatment of glioblastoma" . | VIEW 4 . 3 (2023) . |
| APA | Bian, Yongning , Wang, Yaling , Chen, Xueqian , Zhang, Yong , Xiong, Shaoqing , Su, Dongdong . Image-guided diagnosis and treatment of glioblastoma . | VIEW , 2023 , 4 (3) . |
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Abstract ：
Chemiluminescent probes based on 1,2-dioxetane scaffold are one of the most sensitive imaging modalities for detecting disease-related biomarkers and can obtain more accurate biological information in cells and in vivo. Due to the elimination of external light excitation, the background autofluorescence problem in fluorescence technology can be effectively avoided, providing ultrahigh sensitivity and signal-to-noise ratio for various applications. In this review, we highlight a comprehensive but concise overview of activatable 1,2-dioxetane-based chemiluminescent probes by reporting significant advances in accurate detection and bioimaging. The design principles and applications for reactive species, enzymes, and other disease-related biomarkers are systematically discussed and summarized. The challenges and potential prospects of chemiluminescent probes are also discussed to further promote the development of new chemiluminescence methods for biological analysis and diagnosis.
Keyword ：
Chemiluminescent probes Chemiluminescent probes 2-dioxetane 2-dioxetane Chemiluminescence imaging Chemiluminescence imaging 1 1 in vivo in vivo biomarker biomarker
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| GB/T 7714 | Wang, Yaling , Bian, Yongning , Chen, Xueqian et al. Chemiluminescent Probes Based on 1,2-Dioxetane Structures For Bioimaging [J]. | CHEMISTRY-AN ASIAN JOURNAL , 2022 , 17 (6) . |
| MLA | Wang, Yaling et al. "Chemiluminescent Probes Based on 1,2-Dioxetane Structures For Bioimaging" . | CHEMISTRY-AN ASIAN JOURNAL 17 . 6 (2022) . |
| APA | Wang, Yaling , Bian, Yongning , Chen, Xueqian , Su, Dongdong . Chemiluminescent Probes Based on 1,2-Dioxetane Structures For Bioimaging . | CHEMISTRY-AN ASIAN JOURNAL , 2022 , 17 (6) . |
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Abstract ：
A simple but efficient fluorogenic probe is reported for accurate imaging of ulcerative colitis via hypoxia detection. The hypoxia produced by ulcerative colitis can lead to the upregulation of nitroreductase (NTR). NB-NO2 provides a unique response to NTR, enabling accurate imaging of Dextran sulphate sodium (DSS)-induced ulcerative colitis in vivo.
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| GB/T 7714 | Li, Mingrui , Zhang, Yong , Ren, Xiaojun et al. Activatable fluorogenic probe for accurate imaging of ulcerative colitis hypoxia in vivo [J]. | CHEMICAL COMMUNICATIONS , 2021 , 58 (6) : 819-822 . |
| MLA | Li, Mingrui et al. "Activatable fluorogenic probe for accurate imaging of ulcerative colitis hypoxia in vivo" . | CHEMICAL COMMUNICATIONS 58 . 6 (2021) : 819-822 . |
| APA | Li, Mingrui , Zhang, Yong , Ren, Xiaojun , Niu, Wenchao , Yuan, Qing , Cao, Kai et al. Activatable fluorogenic probe for accurate imaging of ulcerative colitis hypoxia in vivo . | CHEMICAL COMMUNICATIONS , 2021 , 58 (6) , 819-822 . |
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Abstract ：
Phosgene is a suffocating toxic gas that seriously threatens human health and public security. In this work, we devised a colorimetric and fluorogenic chemosensor (BDY) for phosgene by using 3,5-dimethyl BODIPY as a fluorescent reporter and o-phenylenediamine as the recognition site. The BDY sensor displayed an obvious color change from yellow to pink in conjugation with a fluorescence turn-on response due to nucleophilic substitution and cyclization reactions with phosgene. BDY could detect phosgene with a rapid response (9 s), low detection limit (14 nM), and outstanding selectivity. Moreover, BDY-loaded test strips were prepared to serve as portable and sensitive kits for real-time visual monitoring phosgene with good performance.
Keyword ：
Test paper Test paper Phosgene Phosgene Colorimetric Colorimetric Fluorescent sensor Fluorescent sensor BODIPY BODIPY
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| GB/T 7714 | Bian, Yongning , Wang, Yaling , Yuan, Houqun et al. A portable colorimetric and fluorescent sensor for the fast visual detection of phosgene [J]. | DYES AND PIGMENTS , 2021 , 198 . |
| MLA | Bian, Yongning et al. "A portable colorimetric and fluorescent sensor for the fast visual detection of phosgene" . | DYES AND PIGMENTS 198 (2021) . |
| APA | Bian, Yongning , Wang, Yaling , Yuan, Houqun , Bao, Guang-Ming , Su, Dongdong . A portable colorimetric and fluorescent sensor for the fast visual detection of phosgene . | DYES AND PIGMENTS , 2021 , 198 . |
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Abstract ：
Hydrogen sulfide (H2S) has been found to be an important biological regulator that plays important roles in many physiological and pathological processes. Near-infrared (NIR) fluorescent probes capable of selectively detecting H2S in vivo will be useful tools to understand its mechanisms in biological processes. Herein, we reported an easily synthesized and stimuli-responsive NIR fluorescent probe (QCy7-HS) for selective evaluation of endogenous H2S in the living cells and mice. In response to cellular H2S stimulus, QCy7-HS is converted to (tCy7 and shows a unique off-on near-infrared fluorescence signal change. The results of selectivity and kinetic studies indicated that our probe has high H2S binding capacity. Therefore, this probe was used for the fluorescence detection of H2S in cells. Moreover, the probe was applied for study exogenous and endogenous H2S in live mice, indicating that the new probe can be used as an efficient tool on H2S related events in living animals. (C) 2019 Elsevier B.V. All rights reserved.
Keyword ：
In vivo In vivo Fluorescence spectroscopy Fluorescence spectroscopy Near-infrared Near-infrared Off-on Off-on Hydrogen sulfide Hydrogen sulfide Fluorescent probe Fluorescent probe
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| GB/T 7714 | Su, Dongdong , Cheng, Dan , Lv, Yun et al. A unique off-on near-infrared QCy7-derived probe for selective detection and imaging of hydrogen sulfide in cells and in vivo [J]. | SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY , 2020 , 226 . |
| MLA | Su, Dongdong et al. "A unique off-on near-infrared QCy7-derived probe for selective detection and imaging of hydrogen sulfide in cells and in vivo" . | SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY 226 (2020) . |
| APA | Su, Dongdong , Cheng, Dan , Lv, Yun , Ren, Xiaojun , Wu, Qian , Yuan, Lin . A unique off-on near-infrared QCy7-derived probe for selective detection and imaging of hydrogen sulfide in cells and in vivo . | SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY , 2020 , 226 . |
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| GB/T 7714 | Chen, Tianhong , Jiang, Lirong , Yuan, Hou-Qun et al. A flexible paper -based chemosensor for colorimetric and ratiometric fluorescence detection of toxic oxalyl chloride [J]. | SENSORS AND ACTUATORS B-CHEMICAL , 2020 , 319 . |
| MLA | Chen, Tianhong et al. "A flexible paper -based chemosensor for colorimetric and ratiometric fluorescence detection of toxic oxalyl chloride" . | SENSORS AND ACTUATORS B-CHEMICAL 319 (2020) . |
| APA | Chen, Tianhong , Jiang, Lirong , Yuan, Hou-Qun , Zhang, Yue , Su, Dongdong , Bao, Guang-Ming . A flexible paper -based chemosensor for colorimetric and ratiometric fluorescence detection of toxic oxalyl chloride . | SENSORS AND ACTUATORS B-CHEMICAL , 2020 , 319 . |
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Abstract ：
The activatable off-on near-infrared QCy7-based fluorogenic probes have emerged as powerful modalities for detecting and monitoring biological analytes and understanding their biological processes in cells and organisms. The use of biomarker-activated QCy7-based probes enables simple synthesis, minimum photo-damage to biological samples, and minimum background interference from biological systems. In this minireview, we aim to provide a rigorous but concise overview of activatable QCy7-based fluorogenic probes by reporting the significant progress made in recent years. The design strategies and the main applications of accurate detection and imaging of disease-related biomarkers (including ROS/RSS, enzymes, metal ions, and other related species) were reasonably analyzed and discussed. The potential challenges and prospects of activatable QCy7-based fluorogenic probes are also emphasized to further advance the development of new methods for biomarker detection and bioimaging.
Keyword ：
activatable probes activatable probes biomarkers biomarkers bioimaging bioimaging QCy7 QCy7 fluorogenic probes fluorogenic probes
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| GB/T 7714 | Chen, Xueqian , Bian, Yongning , Li, Mingrui et al. Activatable Off-on Near-Infrared QCy7-based Fluorogenic Probes for Bioimaging [J]. | CHEMISTRY-AN ASIAN JOURNAL , 2020 , 15 (23) : 3983-3994 . |
| MLA | Chen, Xueqian et al. "Activatable Off-on Near-Infrared QCy7-based Fluorogenic Probes for Bioimaging" . | CHEMISTRY-AN ASIAN JOURNAL 15 . 23 (2020) : 3983-3994 . |
| APA | Chen, Xueqian , Bian, Yongning , Li, Mingrui , Zhang, Yong , Gao, Xueyun , Su, Dongdong . Activatable Off-on Near-Infrared QCy7-based Fluorogenic Probes for Bioimaging . | CHEMISTRY-AN ASIAN JOURNAL , 2020 , 15 (23) , 3983-3994 . |
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