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学者姓名：徐坤
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Abstract ：
Hepatocellular carcinoma (HCC) is a major global health concern, necessitating innovative therapeutic strategies. In this study, we investigated the functional role of circular RNA circDCUN1D4 in HCC progression and its potential therapeutic implications. It was found that HCC patients exhibiting higher levels of circDCUN1D4 demonstrated a more favorable survival rate. Furthermore, we revealed that circDCUN1D4 suppressed HCC cell proliferation, migration, and invasion. Mechanistically, circDCUN1D4 was identified as a sponge for miR-590-5p, leading to the downregulation of its downstream target, Tissue Inhibitor of Metalloproteinase 3 (TIMP3). Importantly, circDCUN1D4 administration through In vivo jet-PEI exhibited a robust inhibitory effect on tumor progression without causing notable toxicity in mice. Overall, our findings highlight circDCUN1D4 as a promising therapeutic candidate for HCC, unraveling its intricate regulatory role through the miR-590-5p/TIMP3 axis. This study contributes valuable insights into the potential clinical applications of circRNA-based therapies for HCC.
Keyword ：
TIMP3 TIMP3 Hepatocellular carcinoma Hepatocellular carcinoma miR-590-5p miR-590-5p
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| GB/T 7714 | Li, Hongyu , Su, Bing , Jiang, Yan et al. Circular RNA circDCUN1D4 suppresses hepatocellular carcinoma development via targeting the miR-590-5p/ TIMP3 axis [J]. | MOLECULAR CANCER , 2025 , 24 (1) . |
| MLA | Li, Hongyu et al. "Circular RNA circDCUN1D4 suppresses hepatocellular carcinoma development via targeting the miR-590-5p/ TIMP3 axis" . | MOLECULAR CANCER 24 . 1 (2025) . |
| APA | Li, Hongyu , Su, Bing , Jiang, Yan , Zhang, Boyang , Du, Rulong , Song, Can et al. Circular RNA circDCUN1D4 suppresses hepatocellular carcinoma development via targeting the miR-590-5p/ TIMP3 axis . | MOLECULAR CANCER , 2025 , 24 (1) . |
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Abstract ：
The strategic installation of the "magic methyl" group at a certain location in lead compounds has become an important tool for medicinal chemists in the field of drug discovery. Both photochemistry and electrochemistry have witnessed an explosive resurgence in recent years and emerged as a cornerstone of modern organic chemistry. In this review, we conducted an extensive data mining of the literature and provide a comprehensive overview of the recent advancements in utilizing green photochemical and electrochemical methodologies for the incorporation of methyl groups, with specific emphasis on the methyl source, design strategies and reaction mechanisms. These research developments provide sustainable and broadly applicable tools to develop valuable methylated products with major prospects for the pharmaceutical industry. In addition, their applications in the late-stage functionalization of bioactive compounds are also demonstrated. The strategic installation of the "magic methyl" group has become highly desirable for drug discovery. This review summarized the recent photochemical and electrochemical strategies in installing the methyl group.
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| GB/T 7714 | Liao, Feiyang , Wei, Zenghui , Guan, Yunhao et al. Demystifying the recent photochemical and electrochemical strategies in installing the magic methyl group: a comprehensive overview [J]. | GREEN CHEMISTRY , 2024 , 26 (14) : 8161-8203 . |
| MLA | Liao, Feiyang et al. "Demystifying the recent photochemical and electrochemical strategies in installing the magic methyl group: a comprehensive overview" . | GREEN CHEMISTRY 26 . 14 (2024) : 8161-8203 . |
| APA | Liao, Feiyang , Wei, Zenghui , Guan, Yunhao , Zhuang, Zhe , Xu, Kun , Tan, Jiajing . Demystifying the recent photochemical and electrochemical strategies in installing the magic methyl group: a comprehensive overview . | GREEN CHEMISTRY , 2024 , 26 (14) , 8161-8203 . |
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Abstract ：
The reductive activation of chemical bonds at less negative potentials provides a foundation for high functional group tolerance and selectivity, and it is one of the central topics in organic electrosynthesis. Along this line, we report the design of a dual-activation mode by merging electro-reduction with hydrogen bonding activation. As a proof of principle, the reduction potential of N-phenylpropiolamide was shifted positively by 218 mV. Enabled by this strategy, the radical Smiles rearrangement of N-arylpropiolamides without external radical precursors and prefunctionalization steps was accomplished. [DBU][HOAc], a readily accessible ionic liquid, was exploited for the first time both as a hydrogen bonding donor and as a supporting electrolyte. An unprecedented radical smiles rearrangement of N-arylpropiolamides was realized by merging electro-reduction with hydrogen bonding activation. Enabled by this dual activation strategy, the reduction potential was shifted positively by 218 mV.
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| GB/T 7714 | Lan, Liyuan , Xu, Kun , Zeng, Chengchu . The merger of electro-reduction and hydrogen bonding activation for a radical Smiles rearrangement [J]. | CHEMICAL SCIENCE , 2024 , 15 (33) : 13459-13465 . |
| MLA | Lan, Liyuan et al. "The merger of electro-reduction and hydrogen bonding activation for a radical Smiles rearrangement" . | CHEMICAL SCIENCE 15 . 33 (2024) : 13459-13465 . |
| APA | Lan, Liyuan , Xu, Kun , Zeng, Chengchu . The merger of electro-reduction and hydrogen bonding activation for a radical Smiles rearrangement . | CHEMICAL SCIENCE , 2024 , 15 (33) , 13459-13465 . |
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Abstract ：
An I-2-mediated annulation of 3-aminopyrazoles with indole-3-carboxaldehydes has been demonstrated for the first time. This tandem strategy allows the facile construction of indole-pyrimidine-pyrazole-fused tetracyclic heteroarenes that are otherwise inaccessible by the existing methods. These fused heterocycles exhibited enhanced antifungal activities against Valsa mali and Botryosphaeria dothidea compared with commercial Xemium fungicide.
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| GB/T 7714 | Qu, Heng-Tong , Zhou, Long-Sheng , Yang, Jia-Xin et al. I2-Mediated [3+3] Annulation for the Construction of Indole-Pyrimidine-Pyrazole-Fused Tetracyclic Heteroarenes [J]. | JOURNAL OF ORGANIC CHEMISTRY , 2024 , 89 (20) : 15164-15169 . |
| MLA | Qu, Heng-Tong et al. "I2-Mediated [3+3] Annulation for the Construction of Indole-Pyrimidine-Pyrazole-Fused Tetracyclic Heteroarenes" . | JOURNAL OF ORGANIC CHEMISTRY 89 . 20 (2024) : 15164-15169 . |
| APA | Qu, Heng-Tong , Zhou, Long-Sheng , Yang, Jia-Xin , Hong, Jia-Hui , Teng, Fan , Xu, Kun et al. I2-Mediated [3+3] Annulation for the Construction of Indole-Pyrimidine-Pyrazole-Fused Tetracyclic Heteroarenes . | JOURNAL OF ORGANIC CHEMISTRY , 2024 , 89 (20) , 15164-15169 . |
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Abstract ：
A formal [3+3] annulation of 3-aminopyrazoles with cinnamaldehydes or cinnamyl alcohols mediated by NH4SCN has been developed. This protocol provides a practical route to construct 5-arylated pyrazolo[1,5-a]pyrimidines with high functional group tolerance. The use of NH4SCN as the cyanide anion surrogate allows the transient generation of cyanohydrin, which shifts the reactive center within cinnamaldehydes from formyl group to alkene group to realize an opposite regiocontrol comparing with previous reports.
Keyword ：
pyrazolo[1,5-alpha]pyrimidine pyrazolo[1,5-alpha]pyrimidine regioselectivity regioselectivity hypervalent iodine hypervalent iodine tandem cyclization tandem cyclization cinnamaldehyde cinnamaldehyde
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| GB/T 7714 | Li, Longlong , He, Xinyue , Zhou, Longsheng et al. NH4SCN-Promoted Formal [3+3] Annulation for the Synthesis of 5-Arylated Pyrazolo[1,5-a]pyrimidines [J]. | CHINESE JOURNAL OF ORGANIC CHEMISTRY , 2024 , 44 (9) : 2832-2840 . |
| MLA | Li, Longlong et al. "NH4SCN-Promoted Formal [3+3] Annulation for the Synthesis of 5-Arylated Pyrazolo[1,5-a]pyrimidines" . | CHINESE JOURNAL OF ORGANIC CHEMISTRY 44 . 9 (2024) : 2832-2840 . |
| APA | Li, Longlong , He, Xinyue , Zhou, Longsheng , Qu, Hengtong , Feng, Chengtao , Xu, Kun . NH4SCN-Promoted Formal [3+3] Annulation for the Synthesis of 5-Arylated Pyrazolo[1,5-a]pyrimidines . | CHINESE JOURNAL OF ORGANIC CHEMISTRY , 2024 , 44 (9) , 2832-2840 . |
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Abstract ：
While aiming at sustainable synthesis, organic electrosynthesis has attracted increasing attention in the past few years. In parallel, with a deeper understanding of catalyst and ligand design, 3d transition-metal catalysis allows the conception of more straightforward synthetic routes in a cost-effective fashion. Owing to their intrinsic advantages, the merger of organic electrosynthesis with 3d transition-metal catalysis has offered huge opportunities for conceptually novel transformations while limiting ecological footprint. This review summarizes the key advancements in this direction published in the recent two years, with specific focus placed on strategy design and mechanistic aspects. The merger of organic electrosynthesis with 3d transition-metal catalysis has offered huge opportunities for modern organic synthesis. This review summarizes the key advancements in this direction published in the recent two years.
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| GB/T 7714 | Lian, Fei , Li, Jiu-Ling , Xu, Kun . When transition-metal catalysis meets electrosynthesis: a recent update [J]. | ORGANIC & BIOMOLECULAR CHEMISTRY , 2024 , 22 (22) : 4390-4419 . |
| MLA | Lian, Fei et al. "When transition-metal catalysis meets electrosynthesis: a recent update" . | ORGANIC & BIOMOLECULAR CHEMISTRY 22 . 22 (2024) : 4390-4419 . |
| APA | Lian, Fei , Li, Jiu-Ling , Xu, Kun . When transition-metal catalysis meets electrosynthesis: a recent update . | ORGANIC & BIOMOLECULAR CHEMISTRY , 2024 , 22 (22) , 4390-4419 . |
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Abstract ：
An aerobic Mn(III)-catalyzed one-pot three-component synthesis of 5-cyano-pyrazolo[1,5-a]pyrimidines has been described. The synergistic combination of Strecker reaction and oxidatively-induced 6 pi-azacyclization is the key to the success of this multicomponent synthesis. Differing from previous reports relied on toxic cyanating agents or multistep synthesis, this mechanistically distinct protocol serves as a step-economic, regioselective and functionally tolerant strategy to obtain 5-cyano-pyrazolo[1,5-a]pyrimidines.
Keyword ：
Manganese catalysis Manganese catalysis Cyanation Cyanation Multicomponent reaction Multicomponent reaction Strecker reaction Strecker reaction
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| GB/T 7714 | Qu, Heng-Tong , Wu, Zeng-Hui , Zhong, Guo-Chen et al. Multicomponent Synthesis of 5-Cyano-pyrazolo[1,5-a]pyrimidines Enabled by Aerobic Manganese Catalysis [J]. | ADVANCED SYNTHESIS & CATALYSIS , 2023 , 365 (6) : 871-876 . |
| MLA | Qu, Heng-Tong et al. "Multicomponent Synthesis of 5-Cyano-pyrazolo[1,5-a]pyrimidines Enabled by Aerobic Manganese Catalysis" . | ADVANCED SYNTHESIS & CATALYSIS 365 . 6 (2023) : 871-876 . |
| APA | Qu, Heng-Tong , Wu, Zeng-Hui , Zhong, Guo-Chen , Zhang, Yan-Chun , Feng, Cheng-Tao , Xu, Kun . Multicomponent Synthesis of 5-Cyano-pyrazolo[1,5-a]pyrimidines Enabled by Aerobic Manganese Catalysis . | ADVANCED SYNTHESIS & CATALYSIS , 2023 , 365 (6) , 871-876 . |
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Abstract ：
The metal-free alkylation of N-heterocycles with alkenes has remained a synthetic challenge. We report here the successful implementation of metal-free alkylation of quinoxalinones with electron-deficient alkenes enabled by a sequential paired electrolysis. This protocol provides a mechanistically distinct approach to prepare a variety of C-3 alkylated quinoxalinones that are otherwise quite difficult to synthesize by other means. The unprecedented alkylation of quinoxalinones with electron-deficient alkenes has been realized by a sequential paired electrolysis.
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| GB/T 7714 | Wang, Huiqiao , Liu, Ruoyu , Sun, Qi et al. Direct alkylation of quinoxalinones with electron-deficient alkenes enabled by a sequential paired electrolysis [J]. | CHEMICAL COMMUNICATIONS , 2023 , 59 (85) : 12763-12766 . |
| MLA | Wang, Huiqiao et al. "Direct alkylation of quinoxalinones with electron-deficient alkenes enabled by a sequential paired electrolysis" . | CHEMICAL COMMUNICATIONS 59 . 85 (2023) : 12763-12766 . |
| APA | Wang, Huiqiao , Liu, Ruoyu , Sun, Qi , Xu, Kun . Direct alkylation of quinoxalinones with electron-deficient alkenes enabled by a sequential paired electrolysis . | CHEMICAL COMMUNICATIONS , 2023 , 59 (85) , 12763-12766 . |
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| GB/T 7714 | Wang, Huiqiao , Xu, Kun . Cobalta-Electrocatalyzed Allylic C-H Alkylation [J]. | CHINESE JOURNAL OF ORGANIC CHEMISTRY , 2022 , 42 (4) : 1260-1261 . |
| MLA | Wang, Huiqiao et al. "Cobalta-Electrocatalyzed Allylic C-H Alkylation" . | CHINESE JOURNAL OF ORGANIC CHEMISTRY 42 . 4 (2022) : 1260-1261 . |
| APA | Wang, Huiqiao , Xu, Kun . Cobalta-Electrocatalyzed Allylic C-H Alkylation . | CHINESE JOURNAL OF ORGANIC CHEMISTRY , 2022 , 42 (4) , 1260-1261 . |
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Abstract ：
The ubiquity of N-heterocycles in marketed drugs makes the development of metal-free methodologies for constructing C-N bonds of considerable importance. As an environmentally friendly method, electro-oxidative intramolecular C-H amination has emerged as a powerful platform for synthesizing nitrogen-containing heterocycles under metal- and external oxidant-free conditions. In this minireview, the main achievements in this direction since 2020 are summarized, with an emphasis on the substrate scope and mechanistic aspects. The reactions are classified into two categories: direct and indirect electro-oxidative intramolecular C-H aminations.
Keyword ：
Electrosynthesis C-H amination N-heterocycle Indirect electrolysis Electrosynthesis C-H amination N-heterocycle Indirect electrolysis
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| GB/T 7714 | Wang, Huiqiao , Xu, Kun . Direct and Indirect Electro-Oxidative Intramolecular C-H Aminations [J]. | TRANSACTIONS OF TIANJIN UNIVERSITY , 2022 , 28 (6) : 469-481 . |
| MLA | Wang, Huiqiao et al. "Direct and Indirect Electro-Oxidative Intramolecular C-H Aminations" . | TRANSACTIONS OF TIANJIN UNIVERSITY 28 . 6 (2022) : 469-481 . |
| APA | Wang, Huiqiao , Xu, Kun . Direct and Indirect Electro-Oxidative Intramolecular C-H Aminations . | TRANSACTIONS OF TIANJIN UNIVERSITY , 2022 , 28 (6) , 469-481 . |
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