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学者姓名：陈涛
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Abstract ：
The regeneration of the injured nerve and recovery of its function have brought attention in the medical field. Electrical stimulation (ES) can enhance the cellular biological behavior and has been widely studied in the treatment of neurological diseases. Microfluidic technology can provide a cell culture platform with the well-controlled environment. Here a novel microfluidic/microelectrode composite microdevice was developed by embedding the microelectrodes to the microfluidic platform, in which microfluidics provided a controlled cell culture platform, and ES promoted the NSCs proliferation. We performed ES on rat neural stem cells (NSCs) to observe the effect on their growth, differentiation, proliferation, and preliminary explored the ES influence on cells in vitro. The results of immunofluorescence showed that ES had no significant effect on the NSCs specific expression, and the NSCs specific expression reached 98.9% +/- 0.4% after three days of ES. In addition, ES significantly promoted cell growth and the cell proliferation rate reached 49.41%. To conclude, the microfluidic/microelectrode composite microdevice can play a positive role in the nerve injury repair and fundamental research of neurological diseases. (C) 2021 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
Keyword ：
Electrical stimulation Electrical stimulation Microfluidics Microfluidics Microelectrode Microelectrode NSCs NSCs Proliferation Proliferation
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| GB/T 7714 | Li, Qian , Kang, Bodong , Wang, Libin et al. Microfluidics embedded with microelectrodes for electrostimulation of neural stem cells proliferation [J]. | CHINESE CHEMICAL LETTERS , 2022 , 33 (3) : 1308-1312 . |
| MLA | Li, Qian et al. "Microfluidics embedded with microelectrodes for electrostimulation of neural stem cells proliferation" . | CHINESE CHEMICAL LETTERS 33 . 3 (2022) : 1308-1312 . |
| APA | Li, Qian , Kang, Bodong , Wang, Libin , Chen, Tao , Zhao, Yu , Feng, Shilun et al. Microfluidics embedded with microelectrodes for electrostimulation of neural stem cells proliferation . | CHINESE CHEMICAL LETTERS , 2022 , 33 (3) , 1308-1312 . |
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Abstract ：
This paper presents an integrated circuit design for neural recording chip with integrated CMOS electrode array. The implementation of on-chip electrode array can greatly improve the implantability of neural recording systems. The chip is mainly composed of a neural recording analog front end and an 8x8 microelectrode array designed in CMOS process technology. The analog front end of the neural recording circuit adopts chopper technique, which effectively reduces the lowfrequency noise. The whole circuit has been designed in Cadence using the SMIC 180-nm CMOS process. The simulation results show that the signal with a frequency ranging from 0-2kHz and the amplitude ranging from 0-500 mu V can be independently recorded through the electrodes with a control terminal. The electrode array and the recording analog front end IC are partly overlapped using different metal layers, saving the chip area. The chip area of the final circuit with 64 electrodes is only 1400 mu m x 760 mu m.
Keyword ：
neural recording neural recording microelectrode array microelectrode array CMOS CMOS chopper chopper
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| GB/T 7714 | Zhang, Ronghao , Liu, Xu , Chen, Zhijie et al. A Neural Recording IC Design with on-chip CMOS Electrode Array for Brain-machine Interface [J]. | 2022 IEEE ASIA PACIFIC CONFERENCE ON CIRCUITS AND SYSTEMS, APCCAS , 2022 : 139-143 . |
| MLA | Zhang, Ronghao et al. "A Neural Recording IC Design with on-chip CMOS Electrode Array for Brain-machine Interface" . | 2022 IEEE ASIA PACIFIC CONFERENCE ON CIRCUITS AND SYSTEMS, APCCAS (2022) : 139-143 . |
| APA | Zhang, Ronghao , Liu, Xu , Chen, Zhijie , Wan, Peiyuan , Chen, Tao . A Neural Recording IC Design with on-chip CMOS Electrode Array for Brain-machine Interface . | 2022 IEEE ASIA PACIFIC CONFERENCE ON CIRCUITS AND SYSTEMS, APCCAS , 2022 , 139-143 . |
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Abstract ：
To provide a larger area and larger regional selectivity of light stimulation in the application of optogenetics, a multi-channel optogenetic stimulation system with a simple structure, wireless control of stimulation parameters and independent control was developed by our research group. A mu LED chip was used as the light source, and lithography and micro-welding technology were used to fabricate a blue light stimulator with an array light source. The wireless control function of the stimulator was realised using the wireless communication module. The size and weight of the photic stimulator were 46 mm x 30 mm and 7. 134 g, respectively. The results showed that the maximum output optical power of the optrode's surface was 24. 6 mW, which met the requirements of activating neurones by ChR2. The adjustable range of the output optical frequency was 1-500 Hz, while the maximum output error was less than 1%. The adjustable range of the duty cycle was 0-100%, while the maximum distance of the wireless communication was 50 m. This system can be used in the fields of optogenetic regulation, cell culture and fields that require a large area of light. Finally, it provides an effective tool for the regulation and research of neural circuits.
Keyword ：
medical optics medical optics mu LED array mu LED array light stimulation light stimulation optogenetic optogenetic wireless control wireless control
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| GB/T 7714 | Su Liangchuang , Chen Tao . Wireless Stimulation System with Multiple Channels and Independent Regulation for Optogenetics in Vitro [J]. | LASER & OPTOELECTRONICS PROGRESS , 2021 , 58 (19) . |
| MLA | Su Liangchuang et al. "Wireless Stimulation System with Multiple Channels and Independent Regulation for Optogenetics in Vitro" . | LASER & OPTOELECTRONICS PROGRESS 58 . 19 (2021) . |
| APA | Su Liangchuang , Chen Tao . Wireless Stimulation System with Multiple Channels and Independent Regulation for Optogenetics in Vitro . | LASER & OPTOELECTRONICS PROGRESS , 2021 , 58 (19) . |
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Abstract ：
This paper presents chip implementation of the integrated neural recording and stimulation system with stimulation-induced artifact suppression. The implemented chip consists of low-power neural recording circuits, stimulation circuits, and action potential detection circuits. These circuits constitute a closed-loop simultaneous neural recording and stimulation system for biomedical devices, and a proposed artifact suppression technique is used in the system. Moreover, this paper also presents the measurement and experiment results of the implemented 4-to-4 channel neural recording and stimulation chip with 0.18 mu m CMOS technology. The function and efficacy of simultaneous neural recording and stimulation is validated in both in vivo and animal experiments.
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| GB/T 7714 | Liu, Xu , Li, Juzhe , Chen, Tao et al. A Neural Recording and Stimulation Chip with Artifact Suppression for Biomedical Devices [J]. | JOURNAL OF HEALTHCARE ENGINEERING , 2021 , 2021 . |
| MLA | Liu, Xu et al. "A Neural Recording and Stimulation Chip with Artifact Suppression for Biomedical Devices" . | JOURNAL OF HEALTHCARE ENGINEERING 2021 (2021) . |
| APA | Liu, Xu , Li, Juzhe , Chen, Tao , Wang, Wensi , Je, Minkyu . A Neural Recording and Stimulation Chip with Artifact Suppression for Biomedical Devices . | JOURNAL OF HEALTHCARE ENGINEERING , 2021 , 2021 . |
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Abstract ：
本发明提供一种多通道无线光遗传刺激系统及方法，包括上位机、光刺激器以及阵列式刺激光极，所述光刺激器包括多个刺激通道，不同刺激通道与阵列式刺激光极的不同区域电连通，所述上位机用于设置光刺激参数，所述光刺激参数包括脉冲的频率、占空比、刺激时间和一个或多个刺激通道，所述上位机和光刺激器无线连接，所述光刺激器接收上位机设置的光刺激参数，输出电脉冲信号给光刺激参数中刺激通道电连通的阵列式刺激光极的区域。上述方法及系统能独立选择刺激的区域。
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| GB/T 7714 | 陈涛 , 苏良闯 , 赵宇 et al. 多通道无线光遗传刺激系统及方法 : CN202110081735.1[P]. | 2021-01-21 . |
| MLA | 陈涛 et al. "多通道无线光遗传刺激系统及方法" : CN202110081735.1. | 2021-01-21 . |
| APA | 陈涛 , 苏良闯 , 赵宇 , 康博栋 . 多通道无线光遗传刺激系统及方法 : CN202110081735.1. | 2021-01-21 . |
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Abstract ：
Purpose: The study aims to lay a foundational probe for the thorough application microfluidic chips in brain function research with microfluidic chips. Neuron slide culture is a common culture method in vitro, and the microfluidic chip with the artificial network pattern not only can realize neuron cells 3 D culture in vitro, but also limit the extension space of neurite outgrow. Materials and Methods: In order to analyze the differences of hippocampal cells neurite growth length between the 3 D chips and the common 2 D culture, the experiments utilized statistical analysis method analyzing the length of the hippocampus neuron neurite of 3 days, 5 days and 7 days, respectively, with the common glass slide 2 D culture method and the microfluidic chip 3 D culture in vitro. Results: The results showed that there was no significant difference in the neurite length after 3 days. However, there was a significant difference after 5 days and 7 days. It can be seen that the microfluidic chip with artificial network pattern has limitations to the growth of neurite after 5 days. Conclusions: We concluded that the growth state of hippocampal cells in the restricted 3 D space is different from that of conventional 2 D culture.It showed that the artificial network pattern design has limited the growth space of the dendrites but also affected its growth.
Keyword ：
hippocampal cells hippocampal cells artificial network pattern artificial network pattern Microfluidic chip Microfluidic chip the length of neurite the length of neurite
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| GB/T 7714 | Kong, Xianmin , Chen, Tao , Huang, Yinghui . Analysis of neurite length of hippocampal neurons cultured into 3D artificial network patterned microfluidic chips [J]. | INTERNATIONAL JOURNAL OF NEUROSCIENCE , 2020 , 131 (1) : 40-43 . |
| MLA | Kong, Xianmin et al. "Analysis of neurite length of hippocampal neurons cultured into 3D artificial network patterned microfluidic chips" . | INTERNATIONAL JOURNAL OF NEUROSCIENCE 131 . 1 (2020) : 40-43 . |
| APA | Kong, Xianmin , Chen, Tao , Huang, Yinghui . Analysis of neurite length of hippocampal neurons cultured into 3D artificial network patterned microfluidic chips . | INTERNATIONAL JOURNAL OF NEUROSCIENCE , 2020 , 131 (1) , 40-43 . |
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Abstract ：
A novel carbon nanotubes/porous-network carbon micron tubes/silk fibroin (CPS) composite film neural electrode was presented and characterized. This electrode was fabricated through assembling dispersed carbon nanotubes (CNTs) by phytic acid onto the porous silk fibroin film. Afterward, the silk fibroin around the CNTs was carbonized by laser irradiation, producing porous-network carbon microtubes with good conductivity and biological compatibility. The structure of the CPS composite film was characterized by scanning electron microscopy and Raman spectroscopy. Cyclic voltammetry, electrochemical impedance spectroscopy, and safe charge injection limit (Q(inj)) of the CPS electrode were also measured by the three-electrode system, and the results exhibited outstanding electrochemical properties with the achieved Q(inj) of 5.7 mC/cm(2). This work provides a promising approach for the preparation of a long-term implanted neural electrode with high charge injection ability and good biocompatibility.
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| GB/T 7714 | Shen, Xuefei , Zhao, Yu , Li, Qian et al. Construction and electrochemical properties determination of carbon nanotubes/porous-network carbon micron tubes/silk fibroin composite film neural electrode [J]. | AIP ADVANCES , 2020 , 10 (4) . |
| MLA | Shen, Xuefei et al. "Construction and electrochemical properties determination of carbon nanotubes/porous-network carbon micron tubes/silk fibroin composite film neural electrode" . | AIP ADVANCES 10 . 4 (2020) . |
| APA | Shen, Xuefei , Zhao, Yu , Li, Qian , Chen, Tao . Construction and electrochemical properties determination of carbon nanotubes/porous-network carbon micron tubes/silk fibroin composite film neural electrode . | AIP ADVANCES , 2020 , 10 (4) . |
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Abstract ：
本发明公开了一种气溶胶颗粒分选系统及方法，包括：驱动装置，用于将辅助气体和气溶胶样品以设定的速度比注入筛分装置中；筛分装置，用于对气溶胶样品进行分选；其中，所述筛分装置包括：微流控芯片，至少具有相互交叉的两个通道，用于对注入的气溶胶样品进行分流；芯片夹具，用于夹持所述微流控芯片；收集腔，位于所述微流控芯片的下方，用于收集气溶胶样品内的颗粒；通过驱动装置注入气溶胶样品和辅助气体，驱使所述气溶胶样品以单颗粒形式逐一通过所述微流控芯片内的第一通道，进入所述收集腔中。本发明可实现一种或多种颗粒的气溶胶的粒子分选要求，大幅度的提高分选效率、提高分选精度、降低设备复杂性、简化操作流程。
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| GB/T 7714 | 张晨 , 陈涛 , 赵宇 . 气溶胶颗粒分选系统及方法 : CN202011412837.9[P]. | 2020-12-03 . |
| MLA | 张晨 et al. "气溶胶颗粒分选系统及方法" : CN202011412837.9. | 2020-12-03 . |
| APA | 张晨 , 陈涛 , 赵宇 . 气溶胶颗粒分选系统及方法 : CN202011412837.9. | 2020-12-03 . |
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Abstract ：
本发明提供一种微流控平台、制备方法及其应用，包括多个培养室，培养室之间通过微通道连接，所述微通道的深度通过培养室内的细胞或组织的轴突确定，使得轴突通过所述微通道，轴突对应的细胞和组织无法通过所述微通道，不同培养室的细胞或组织通过轴突连接。本发明对受损神经细胞或组织进行物理和流体隔离，实现共培养。
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| GB/T 7714 | 李倩 , 陈涛 . 微流控平台、制备方法及其应用 : CN202011624365.3[P]. | 2020-12-31 . |
| MLA | 李倩 et al. "微流控平台、制备方法及其应用" : CN202011624365.3. | 2020-12-31 . |
| APA | 李倩 , 陈涛 . 微流控平台、制备方法及其应用 : CN202011624365.3. | 2020-12-31 . |
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Abstract ：
In this paper, we present a novel optical microfluidic cytometry scheme for label-free detection of cells that is based on the self-mixing interferometry (SMI) technique. This device enables simple, fast and accurate detection of the individual cell characteristics and efficient cell type classification. We also propose a novel parameter to classify the cell or particle size. Artificial polystyrene beads and human living cells were measured using this system, and the SMI signal properties were statistically evaluated. The capability of the proposed cytometer for cell type discrimination and size classification has been validated by the measurement results. Our study can provide a very simple technique for cell enumeration and classification without any extra devices such as high-speed camera, photomultiplier and spectrometer. Moreover, the fluorescence staining operation which is necessary in traditional flow cytometry methods is not required either in our system.
Keyword ：
flow cytometry flow cytometry self-mixing interferometry self-mixing interferometry label-free label-free microfluidic chip microfluidic chip hydrodynamic focusing hydrodynamic focusing
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| GB/T 7714 | Zhao, Yu , Shen, Xuefei , Zhang, Menglei et al. Self-Mixing Interferometry-Based Micro Flow Cytometry System for Label-Free Cells Classification [J]. | APPLIED SCIENCES-BASEL , 2020 , 10 (2) . |
| MLA | Zhao, Yu et al. "Self-Mixing Interferometry-Based Micro Flow Cytometry System for Label-Free Cells Classification" . | APPLIED SCIENCES-BASEL 10 . 2 (2020) . |
| APA | Zhao, Yu , Shen, Xuefei , Zhang, Menglei , Yu, Jingwen , Li, Jintao , Wang, Xiuhong et al. Self-Mixing Interferometry-Based Micro Flow Cytometry System for Label-Free Cells Classification . | APPLIED SCIENCES-BASEL , 2020 , 10 (2) . |
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