Over　the　past　two　decades,　various　Alzheimer＇s　disease　(AD)　trangenetic　mice　models　harboring　genes　with　mutation　known　to　cause　familial　AD　have　been　created.　Today,　high-resolution　magnetic　resonance　microscopy　(MRM)　technology　is　being　widely　used　in　the　study　of　AD　mouse　models.　It　has　greatly　facilitated　and　advanced　our　knowledge　of　AD.　In　this　review,　most　of　the　attention　is　paid　to　fundamental　of　MRM,　the　construction　of　standard　mouse　MRM　brain　template　and　atlas,　the　detection　of　amyloid　plaques,　following　up　on　brain　atrophy　and　the　future　applications　of　MRM　in　transgenic　AD　mice.　It　is　believed　that　future　testing　of　potential　drugs　in　mouse　models　with　MRM　will　greatly　improve　the　predictability　of　drug　effect　in　preclinical　trials.　Microsc.　Res.　Tech.　78:416-424,　2015.　(c)　2015　Wiley　Periodicals,　Inc.