• Complex
  • Title
  • Keyword
  • Abstract
  • Scholars
  • Journal
  • ISSN
  • Conference
搜索

Author:

Zhang, Yuan (Zhang, Yuan.) | Cheng, Yue (Cheng, Yue.) | Ge, Liang (Ge, Liang.) | Du, Nan (Du, Nan.) | Jia, Kebin (Jia, Kebin.) (Scholars:贾克斌) | Zhang, Aidong (Zhang, Aidong.)

Indexed by:

Scopus SCIE

Abstract:

Many clustering methods have been developed to identify functional modules in Protein-Protein Interaction (PPI) networks but the results are far from satisfaction. To overcome the noise and incomplete problems of PPI networks and find more accurate and stable functional modules, we propose an integrative method, bipartite graph-based Non-negative Matrix Factorisation method (BiNMF), in which we adopt multiple biological data sources as different views that describe PPIs. Specifically, traditional clustering models are adopted as preliminary analysis of different views of protein functional similarity. Then the intermediate clustering results are represented by a bipartite graph which can comprehensively represent the relationships between proteins and intermediate clusters and finally overlapping clustering results are achieved. Through extensive experiments, we see that our method is superior to baseline methods and detailed analysis has demonstrated the benefits of integrating diverse clustering methods and multiple biological information sources.

Keyword:

PPI functional module detection protein-protein interaction networks non-negative matrix factorisation consensus mining multiple data sources integration

Author Community:

  • [ 1 ] [Zhang, Yuan]Beijing Univ Technol, Dept Elect Informat & Control Engn, Beijing 100124, Peoples R China
  • [ 2 ] [Cheng, Yue]Beijing Univ Technol, Dept Elect Informat & Control Engn, Beijing 100124, Peoples R China
  • [ 3 ] [Jia, Kebin]Beijing Univ Technol, Dept Elect Informat & Control Engn, Beijing 100124, Peoples R China
  • [ 4 ] [Ge, Liang]SUNY Buffalo, Dept Comp Sci & Engn, Buffalo, NY 14260 USA
  • [ 5 ] [Du, Nan]SUNY Buffalo, Dept Comp Sci & Engn, Buffalo, NY 14260 USA
  • [ 6 ] [Zhang, Aidong]SUNY Buffalo, Dept Comp Sci & Engn, Buffalo, NY 14260 USA

Reprint Author's Address:

  • 贾克斌

    [Jia, Kebin]Beijing Univ Technol, Dept Elect Informat & Control Engn, Beijing 100124, Peoples R China

Show more details

Related Keywords:

Source :

INTERNATIONAL JOURNAL OF DATA MINING AND BIOINFORMATICS

ISSN: 1748-5673

Year: 2015

Issue: 2

Volume: 13

Page: 122-140

0 . 3 0 0

JCR@2022

ESI Discipline: COMPUTER SCIENCE;

ESI HC Threshold:168

JCR Journal Grade:4

CAS Journal Grade:4

Cited Count:

WoS CC Cited Count: 1

SCOPUS Cited Count: 1

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 5

Online/Total:433/10804457
Address:BJUT Library(100 Pingleyuan,Chaoyang District,Beijing 100124, China Post Code:100124) Contact Us:010-67392185
Copyright:BJUT Library Technical Support:Beijing Aegean Software Co., Ltd.