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Author:

Zhang, X. C. (Zhang, X. C..) | Liu, S. Q. (Liu, S. Q..) | Ren, H. X. (Ren, H. X..) | Zeng, Y. J. (Zeng, Y. J..) | Zhan, G. X. (Zhan, G. X..)

Indexed by:

Scopus SCIE

Abstract:

In the cerebellum, long-term depression (LTD) plays a key function in sculpting neuronal circuits to store information, since motor learning and memory are thought to be associated with such long-term changes in synaptic efficacy. To better understand the principles of transmission of information in the cerebellum, we, in our model, distinguished different types of neurons (type 1- and type 2-like) to examine the neuronal excitability and analyze the interspike interval (ISI) bifurcation phenomenon in these units, and then built a Purkinje cell circuit to study the impact of external stimulation on LTD in this circuit. According to the results of computational analysis, both climbing fiber-Purkinje cell and granule cell-Purkinje cell circuits were found to manifest LTD; the external stimuli would influence LTD by changing both depression time and depression intensity. All of the simulated results showed that LTD is a very significant factor in the Purkinje circuit networks. Finally, to deliver the learning regularities, we simulated spike timing-dependent plasticity (STDP) by increasing the CaP conductance.

Keyword:

long-term depression (LTD) depression time ion currents spike timing-dependent plasticity (STDP) interspike interval (ISI) depression intensity

Author Community:

  • [ 1 ] [Zhang, X. C.]S China Univ Technol, Dept Math, Guangzhou, Guangdong, Peoples R China
  • [ 2 ] [Liu, S. Q.]S China Univ Technol, Dept Math, Guangzhou, Guangdong, Peoples R China
  • [ 3 ] [Ren, H. X.]S China Univ Technol, Dept Math, Guangzhou, Guangdong, Peoples R China
  • [ 4 ] [Zhan, G. X.]S China Univ Technol, Dept Math, Guangzhou, Guangdong, Peoples R China
  • [ 5 ] [Zeng, Y. J.]Beijing Univ Technol, Ctr Biomed Engn, Beijing, Peoples R China

Reprint Author's Address:

  • [Zhang, X. C.]S China Univ Technol, Dept Math, Guangzhou, Guangdong, Peoples R China

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Source :

NEUROPHYSIOLOGY

ISSN: 0090-2977

Year: 2014

Issue: 1

Volume: 46

Page: 25-32

0 . 5 0 0

JCR@2022

ESI Discipline: NEUROSCIENCE & BEHAVIOR;

ESI HC Threshold:275

JCR Journal Grade:4

CAS Journal Grade:4

Cited Count:

WoS CC Cited Count: 0

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 3

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