The　fatigue　behaviour　of　nickel-based　GH4169　alloy　was　studied　under　multiaxial　loading　at　650　degrees　C.　During　the　middle　and　late　stages　of　the　fatigue　life　at　650　degrees　C,　the　axial　and　shear　maximum　stresses　continue　to　decrease　and　plastic　strains　continue　to　increase,　while　at　360　degrees　C　different　phenomena　are　observed.　The　intergranular　cracks　and　certain　quantities　oxygen　were　observed　in　the　fracture　surfaces.　The　damage　of　creep　and　oxidation　are　related　to　temperature　and　strain　range.　The　life　prediction　results　with　a　time-dependent　fatigue　damage　model　show　the　time-related　factors　have　a　certain　influence　on　the　fatigue　damage.