There　is　an　increased　public　concern　about　potential　health　hazards　of　exposure　to　electromagnetic　radiation　(EMR).　To　declare　the　carcinogenic　effects　of　1800　MHz　EMR.　In　this　study,　Balb/c-3T3　cells　were　exposed　to　1800　MHz　EMR　for　80　days.　The　cells　were　harvested　for　cell　proliferation　detection,　cell　cycle　assay,　plate　clone,　and　soft　agar　formation　assay,　transwell　assay,　and　mRNA　microarray　detection.　1800　MHz　EMR　promoted　Balb/c-3T3　proliferation.　No　clones　were　observed　in　both　plate　clone　and　soft　agar　clone　formation　assay.　The　percentage　of　cells　in　S　phase　in　Balb/c-3T3　cells　of　80d　Expo　was　obviously　higher　than　the　percetage　in　80d　Sham　cells.　80d　Expo　Balb/c-3T3　cells　had　stronger　migration　ability　than　Sham　cells.　The　mRNA　microarray　results　indicated　that　cell　cycle,　cell　division,　and　DNA　replication　were　the　main　biological　processes　the　significant　genes　enriched,　with　higher　expression　of　RPs　and　Mcms.　1800　MHz　EMR　promoted　Balb/c-3T3　cells　proliferation　and　migration.　The　mRNA　microarray　results　indicated　that　cell　cycle,　cell　division,　and　DNA　replication　were　the　main　biological　processes　the　significant　genes　enriched.