Organic　solvent　nanofiltration　(OSN)　is　emerging　as　an　efficient　and　emerging　approach　for　separation　and　purification　of　solute　from　organic　solvents,　which　however　were　severely　underdeveloped　because　of　the　low　permeance　of　membranes.　Herein,　a　novel　mixed　matrix　membrane　(MMM)　was　developed　by　incorporation　of　modified　mesoporous　silica　nanoparticle　(MSN)　into　commercially-available　polydimethylsiloxane　(PDMS)　matrix　for　removal　of　trace　impurities,　such　as　Evans　blue　or　vitamin　B12,　from　different　organic　solvents.　Notably,　because　of　the　designed　nanoscale　spaces　originated　from　MSN,　the　permeance　of　the　optimized　MMM　reached　up　to　31.2　L　m(-2).h(-1).MPa-1,　around　17-fold　enhancement　compared　with　that　of　pristine　PDMS　membrane.　Low-field　nuclear　magnetic　resonance　was　employed　to　trace　the　solvent　state　in　the　MMM.　The　MMM　exhibited　high　MeOH　absorption　capability　but　low-swelling　attribute,　certificating　the　high　permeance　and　long-term　stability　of　the　MMM.　The　MMM　was　stably　tested　in　MeOH　solution　for　more　than　80　h,　indicating　the　great　promise　for　future　practical　OSN　applications.