Objective:　The　objectives　of　this　study　were　to　assess　the　hemodynamic　properties　of　the　newly　developed　artificial　heart　valve　prosthesis　experimentally　in　laboratory　simulation.　in　an　animal　model,　and　clinically　in　a　human　model　and　to　compare　the　results　measured　by　catheterization　and　echocardiography.　Methods:　(1)　Laboratory　simulation.　The　prosthesis　was　tested　using　a　pulsatile　flow　simulator　in　the　aortic　position.　Hydrodynamics　parameters　were　automatically　analyzed　through　a　custom-designed　data　processing　program.　(2)　Animal　experiment.　Six　sheep　subjected　to　mitral　replacement　with　21-mm-valve　prosthesis　were　measured　by　open　cardiac　catheterization　intraoperatively.　Doppler　echocardiography　and　open　cardiac　catheterization　under　dobutamine　stress　were　performed　in　two　sheep　subjected　to　implantation　2.5　years　ago.　(3)　Clinical　patient　observation.　Observations　were　carried　out　on　14　patients　with　aortas　replacement　and　10　patients　with　bicuspid　replacement　using　both　doppler　echocardiography　and　open　cardiac　catheterization.　Results:　(1)　Laboratory　simulation.　The　results　showed　that　the　value　of　the　transvalvular　gradient　(Delta　P)　decreased　with　the　increase　of　heart　rate,　and　the　values　were　not　greater　that　10　mm　Hg　at　any　given　tissue　annulus　diameter.　(2)　Animal　experiment.　The　mean　Delta　P　value　of　the　six　sheep　was　5.2　+/-　1.7　mm　Hg　intraoperatively,　while　the　corresponding　Delta　P　value　of　the　two　sheep　2.5　years　after　implantation　was　6.1　+/-　0.3　mm　Hg　measured　by　open　cardiac　catheterization.　(3)　Clinical　patient　observation.　The　mean　Delta　P　values　in　the　aortic　position　measured　by　catheterization　and　echocardiography　were　6.26　similar　to　4.10　and　9.42　similar　to　7.48　mm　Hg,　respectively.　The　gradients　in　the　mitral　position　were　2.10　similar　to　1.9　and　5.28　similar　to　4.10　mm　Hg,　respectively.　Conclusions:　The　results　demonstrate　that　the　new-type　bileaflet　heart　valve　prosthesis　only　generates　a　relatively　low　transvalvar　gradient　and　thus　has　good　hemodynamic　properties.