Background　and　Objectives:　The　treatment　benefits　of　enhanced　external　counterpulsation　(EECP)　heavily　depends　on　hemodynamics.　Global　hemodynamics　of　EECP　can　cause　blood　flow　redistribution　in　the　circulatory　system　whereas　local　hemodynamic　effects　act　on　vascular　endothelial　cells　(VECs).　Local　hemodynamic　effects　of　EECP　on　VECs　are　important　in　the　treatment　of　atherosclerosis,　but　currently　cannot　be　not　evaluated.　Herein　we　aim　to　establish　evaluation　models　of　local　hemodynamic　effects　based　on　the　global　hemodynamic　indicators.　Methods:　We　established　0D/3D　geometric　multi-scale　hemodynamic　models　of　the　coronary　and　cerebral　artery　of　two　healthy　individuals　to　calculate　the　global　hemodynamic　indicators　and　the　local　hemodynamic　effects.　Clinical　EECP　trials　were　performed　to　verify　the　accuracy　of　the　multi-scale　hemodynamic　model.　The　global　hemodynamic　indicators　included　diastolic　blood　pressure/systolic　blood　pressure　(Q　=　D/S),　mean　arterial　pressure　(MAP),　internal　carotid　artery　flow　(ICAF)　and　cerebral　blood　flow　(CBF),　whereas　local　hemodynamic　effects　focused　on　time-averaged　wall　shear　stress　(TAWSS).　The　correlation　between　these　indicators　was　analyzed　via　Pearson　correlation　coefficient.　Significantly　related　indicators　were　selected　for　curve-fitting　to　establish　evaluation　models　of　the　coronary　and　cerebral　artery.　Moreover,　clinical　data　of　a　coronary　heart　disease　patient　and　a　cerebral　ischemic　stroke　patient　were　collected　to　verify　the　effectiveness　of　the　application　of　the　established　evaluation　models　to　real　patients.　Results:　For　coronary　artery,　TAWSS　was　correlated　to　Q　=　D/S　and　ICAF　(P　＜　0.05),　whereas　for　cerebral　artery,　TAWSS　was　correlated　to　MAP　and　CBF　(P　＜　0.05).　The　mean　square　error　(MSE)　between　the　evaluated　values　using　evaluation　model　and　the　calculated　values　using　0D/3D　model　of　TAWSS　of　the　coronary　and　cerebral　artery　were　5.4%　and　1.0%,　respectively.　The　MSE　of　evaluation　model　applied　to　real　patients　was　greater　than　that　applied　to　healthy　individuals,　but　within　an　acceptable　range.　Conclusions:　The　presented　error　demonstrated　validity　and　accuracy　of　the　evaluation　models　in　clinical　patients.　Based　on　the　evaluation　models,　global　hemodynamic　indicators　could　be　used　to　evaluate　the　local　hemodynamic　effects　under　the　current　counterpulsation　mode.　With　TAWSS　range　of　4-7　Pa　as　the　target　range,　EECP　strategies　can　further　be　optimized.　(C)　2021　Elsevier　B.V.　All　rights　reserved.