Pre-operative　correction　trajectory　planning　is　one　of　the　important　aspects　of　deformity　correction.　Avoidance　of　limb-frame　interference　is　essential　to　verify　the　implementability　of　the　preplanned　correction　trajectory,　as　well　as　to　maintain　the　continuity　and　security　of　the　correction　strategy.　In　this　study,　a　novel　interference　inspection　algorithm　is　developed　to　investigate　the　interaction　of　the　limb　and　hexapod　frame　in　the　treatment　of　lower　limb　deformities.　The　algorithm　is　built　on　a　minimum　distance　model　of　the　cone　frustum　busbar　and　cylindrical　axis　using　vector　analysis.　A　predefined　trajectory　is　generated　by　Cartesian　coordinate　path　control.　Subsequently,　an　interference　case　is　performed　through　numerical　simulation　and　motion　simulation.　The　results　show　that　the　conclusion　of　numerical　simulation　and　motion　simulation　is　consistent,　which　prove　the　feasibility　of　the　algorithm.　The　results　also　show　that　it　is　possible　to　identify　the　riskiest　struts,　which　are　prone　to　interfere　with　the　limb,　and　the　riskiest　positions.　The　proposed　algorithm　can　support　the　clinician　in　selecting　the　suitable　frame　configuration　to　avoid　interference.　The　algorithm　solves　the　problem　that　the　interference　can　only　be　judged　by　clinical　observation　in　the　clinic.