In　the　heterogeneous　electro-Fenton　(EF)　system,　high-efficiency　and　durable　materials　have　attracted　wide-spread　attention　as　cathodes　for　degradation　of　refractory　organic　pollutants.　In　this　study,　a　stable　Cu/Fe　oxide　modified　graphite　felt　electrode　(Cu0.33Fe0.67NBDC-300/GF)　was　fabricated　via　a　one-step　hydrothermal　method　and　subsequent　thermal　treatment,　which　used　a　bimetallic　metal-organic　framework　(MOF)　with　2-aminoter-ephthalic　acid　(NH2BDC)　ligand　as　the　precursor.　The　Cu(0.3)3Fe(0.67)NBDC-300/GF　electrode　was　used　as　the　cathode　for　sulfamethoxazole　(SMX)　degradation　in　the　heterogeneous　EF　process.　The　coexistence　of　the　Fe-II/　Fe-III　and　Cu-I/Cu-II　redox　couples　significantly　accelerates　the　regeneration　of　Fe-II　and　promotes　the　generation　of　active　free　radicals　(center　dot　OH　and　center　dot　O-2(-)　).　Fe-IV　was　detected　during　the　process,　which　indicates　that　the　high-valent　iron-oxo　species　was　produced　in　near-neutral　pH　conditions.　The　removal　efficiency　of　SMX　(10　mg　L-1)　can　reach　100.0%　within　75　min　over　a　wide　pH　range　(4.0-9.0).　After　five　cycles,　the　electrode　retained　a　high　stability　and　an　outstanding　catalytic　capacity.　Furthermore,　the　mechanisms　and　pathways　for　SMX　degradation　were　proposed,　the　products　and　intermediates　of　SMX　were　analyzed,　and　the　toxicity　was　evaluated.　It　was　found　that　the　toxicity　decreased　after　degradation.　This　study　displays　a　novel　strategy　for　building　an　efficient　and　stable　self-supporting　electrode　for　treating　antibiotic　wastewater.