Heterogeneous　electro-Fenton　(hetero-EF)　catalysts　exhibit　low　electrocatalytic　performance　and　poor　stability.　To　improve　the　performance　of　a　hetero-EF　process　for　pollutant　degradation,　an　efficient　and　stable　electrode　consisting　of　a　CuFe2O4/Cu2O/Cu　catalyst　on　etched　graphite　felt　(EGF)　was　synthesized　in　this　study.　The　CuFe2O4/Cu2O/Cu@EGF　electrode　demonstrated　good　performance　under　the　applied　pH　range,　high　stability,　good　resistance　to　the　effects　of　other　substances　in　the　water　environment,　and　high　efficiency　toward　the　degradation　of　other　pollutants.　The　degradation　mechanism　was　proposed　based　on　experimental　results　and　theoretical　calculation.　Mass　spectrum　analysis　and　theoretical　calculations　were　employed　to　identify　the　intermediate　products　produced　during　sulfamethoxazole　degradation,　and　the　probable　degradation　pathways　were　proposed.　Finally,　the　toxicity　of　intermediates　produced　during　the　degradation　process　was　evaluated　by　toxicological　simulation　and　experiments　performed　using　Escherichia　coli　and　Chlorella.　These　results　provide　a　theoretical　basis　for　the　efficient　removal　of　antibiotics　present　in　wastewater.　©　2023　Elsevier　B.V.