This　study　aimed　to　further　improve　the　degradation　efficiency　of　pollutants　by　electrochemical　oxidation　system　and　reduce　the　consumption　of　electric　energy.　A　simple　method　of　electrochemical　exfoliation　was　used　to　modify　graph-ite　felt　(GF)　to　prepare　an　anode　material　(Ee-GF)　with　high　degradation　performance.　An　anode　and　cathode　cooper-ative　oxidation　system　was　constructed　with　Ee-GF　as　the　anode　and　CuFe2O4/Cu2O/Cu@EGF　as　the　cathode　to　efficiently　degrade　sulfamethoxazole　(SMX).　Complete　degradation　of　SMX　was　achieved　within　30　min.　Compared　with　anodic　oxidation　system　alone,　the　degradation　time　of　SMX　was　reduced　by　half　and　the　energy　consumption　was　reduced　by　66.8　%.　The　system　displayed　excellent　performance　for　the　degradation　of　different　concentrations　(10-50　mg　L-1)　of　SMX,　different　pollutants,　and　under　different　water　quality　conditions.　In　addition,　the　system　still　maintained　91.7　%　removal　rate　of　SMX　after　ten　consecutive　runs.　At　least　12　degradation　products　and　seven　possible　degradation　routes　of　SMX　were　generated　in　the　degradation　process　by　the　combined　system.　The　eco-toxicity　of　degradation　products　of　SMX　was　reduced　after　the　proposed　treatment.　This　study　provided　a　theoretical　basis　for　the　safe,　efficient,　and　low　energy　consumption　removal　of　antibiotic　wastewater.