As　the　bearer　of　wet　load,　the　desiccant　wheel　determines　the　performance　of　the　rotary　wheel　dehumidification　system.　In　this　study,　a　novel　metal　organic　framework　composite　adsorbent　desiccant　wheel　(MOF　DW)　was　prepared　by　impregnating-spraying　method.　The　complete　rotary　wheel　dehumidification　system　was　built　to　compare　the　dehumidification　performance　of　MOF　DW　and　commercially　silica　gel　desiccant　wheel　(SG　DW).　The　experimental　results　showed　that　increasing　the　rotation　speed　appropriately　improves　the　utilization　ratio　of　regenerative　energy　and　dehumidification　capacity　of　MOF　DW　at　high　ambient　humidity　ratio.　The　temperature　rise　at　the　inlet　and　outlet　of　MOF　DW　is　lower　than　that　of　SG　DW　at　low　ambient　humidity　ratios,　and　the　opposite　is　true　at　high　ambient　humidity　ratios.　In　addition,　the　dehumidification　capacity　and　coefficient　of　performance　of　the　MOF　DW　increase　by　40%-48%　and　13%-19%,　respectively,　compared　with　those　of　the　SG　DW　at　the　regeneration　temperature　of　50　degrees　C.