Reducing　the　consumption　of　high-grade　energy　on　the　regeneration　side　is　crucial　to　decreasing　the　energy　consumption　of　the　desiccant　wheel　system.　Metal-organic　framework　desiccants　exhibit　superior　moisture　ab-sorption　performance.　However,　there　has　been　no　research　on　the　application　of　metal-organic　framework　materials　in　desiccant　wheel　systems　for　low-grade　heat　source　regeneration.　To　address　this　research　gap,　this　study　applied　a　composite　adsorbent　of　the　metal-organic　framework　in　a　heat　pump-desiccant　wheel　system　and　experimentally　evaluated　the　performance　of　the　heat　pump-metal-organic　framework　desiccant　wheel　system　using　low-grade　heat　sources　under　different　operating　conditions.　A　comparison　was　made　with　electrically　heated　desiccant　wheel　systems　and　heat　pump-desiccant　wheel　systems　using　traditional　silica　gel　adsorbents.　The　results　showed　that　the　optimal　desiccant　wheel　rotational　speed　was　8.63　r　&　sdot;h-1,　and　the　optimal　airflow　was　300　m3　&　sdot;h-1.　The　energy　consumption　of　the　heat　pump-metal-organic　framework　desiccant　wheel　system　was　only　42.77%　of　that　of　the　electrically　heated　desiccant　wheel　system,　and　its　dehumidification　energy　factor　was　2.07,　which　is　higher　than　that　of　the　heat　pump-silica　gel　desiccant　wheel　system.　This　demonstrates　the　feasibility　and　efficiency　of　utilizing　low-grade　heat　sources　for　regeneration　using　metal-organic　framework　desiccants　in　practical　applications.